CSNK1A1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| casein kinase 1 alpha 1 | MIM:600505 | Ensembl:ENSG00000113712 | HGNC:HGNC:2451 | PA26951 | 5q32 |
GO terms in CSNK1A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IEA | GO:0007049 | cell cycle |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0045104 | intermediate filament cytoskeleton organization |
| BP | IEA | GO:0051301 | cell division |
| BP | IC | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:1904424 | regulation of GTP binding |
| BP | TAS | GO:1904885 | beta-catenin destruction complex assembly |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| CC | TAS | GO:0005929 | cilium |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0030877 | beta-catenin destruction complex |
| CC | ISS | GO:0036064 | ciliary basal body |
| CC | IDA | GO:0045095 | keratin filament |
| CC | IEA | GO:1990904 | ribonucleoprotein complex |
| MF | ISS | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
Gene expression in normal tissue: CSNK1A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSNK1A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | foxopathway | FoxO family signaling |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p53regulationpathway | p53 pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP3664 | Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196299 | Beta-catenin phosphorylation cascade |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-4839735 | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| reactome | R-HSA-4839743 | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| reactome | R-HSA-4839744 | truncated APC mutants destabilize the destruction complex |
| reactome | R-HSA-4839748 | AMER1 mutants destabilize the destruction complex |
| reactome | R-HSA-5339716 | Misspliced GSK3beta mutants stabilize beta-catenin |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358747 | S33 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358749 | S37 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358751 | S45 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358752 | T41 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5467337 | APC truncation mutants have impaired AXIN binding |
| reactome | R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex |
| reactome | R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex |
| reactome | R-HSA-5610783 | Degradation of GLI2 by the proteasome |
| reactome | R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5635838 | Activation of SMO |
| reactome | R-HSA-5635838 | Activation of SMO |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 4 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD307 | Manumycin A | 5 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD177 | Teniposide | 5 |
| iGMDRD511 | CHEMBL399379 | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD427 | ABT737 | 9 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD1008 | SR-II-138A | 5 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD201 | SKI II | 4 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSNK1A1
CLASSFICATION
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