EPHA3


Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor A3MIM:179611Ensembl:ENSG00000044524HGNC:HGNC:3387PA278193p11.1

GO terms in EPHA3


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005576extracellular region
CCIBAGO:0005737cytoplasm
CCIDAGO:0005769early endosome
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0043005neuron projection
CCIBAGO:0043235receptor complex
BPIEAGO:0007155cell adhesion
BPIBAGO:0007275multicellular organism development
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0010717regulation of epithelial to mesenchymal transition
BPIMPGO:0010976positive regulation of neuron projection development
BPISSGO:0016477cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIDAGO:0032956regulation of actin cytoskeleton organization
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043087regulation of GTPase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIDAGO:0045806negative regulation of endocytosis
BPIDAGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPIDAGO:0051893regulation of focal adhesion assembly
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070507regulation of microtubule cytoskeleton organization
BPIMPGO:0071300cellular response to retinoic acid
BPISSGO:0097155fasciculation of sensory neuron axon
BPISSGO:0097156fasciculation of motor neuron axon
BPIDAGO:1903078positive regulation of protein localization to plasma membrane
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIDAGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding

Gene expression in normal tissue: EPHA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA3


DatabasePathway IDPathway Des.
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
pidepha_fwdpathwayEPHA forward signaling
netpathPathway_TCRTCR
kegghsa04360Axon guidance - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 123
iGMDRD474Avrainvillamide3
iGMDRD260FQI-26
iGMDRD207Capsaicin2
iGMDRD870BRD636103
iGMDRD318PAC-13
iGMDRD441TW 372
iGMDRD398Sepantronium3
iGMDRD506Fedratinib3
iGMDRD64Parbendazole7
iGMDRD60Quinoclamine2
iGMDRD444Tivantinib1
iGMDRD23Gossypol4
iGMDRD903EPHA3 inhibitor2
iGMDRD151CHM-19
iGMDRD433Lexibulin2
iGMDRD446LY 21832401
iGMDRD152179324-69-71
iGMDRD193Fqi17
iGMDRD61Kinetin riboside4
iGMDRD280CYTOCHALASIN B8
iGMDRD394BX-7952
iGMDRD202Curcumin2
iGMDRD5Tyrphostin AG 14783
iGMDRD6AM-5802
iGMDRD705Nakiterpiosin7
iGMDRD221Tamoxifen4
iGMDRD481Dactolisib5
iGMDRD882CIL412
iGMDRD67PENFLURIDOL2
iGMDRD414MST-3125
iGMDRD662JQ-11
iGMDRD329Merck602
iGMDRD246NPC262
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib1
iGMDRD322FK 8662
iGMDRD82Quiflapon2
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2
iGMDRD150RITA2
iGMDRD116CD4375
iGMDRD583LDN 1931891
iGMDRD701NVP-AUY9226
iGMDRD698Neratinib1
iGMDRD123Isoevodiamine6
iGMDRD901ELCPK5
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD945ML2142
iGMDRD435BI-25363

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA3

​​​​