PAX5


Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
paired box 5MIM:167414Ensembl:ENSG00000196092HGNC:HGNC:8619PA329599p13.2

GO terms in PAX5


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006959humoral immune response
BPTASGO:0007275multicellular organism development
BPIEAGO:0007283spermatogenesis
BPIEAGO:0007568aging
BPTASGO:0009887animal organ morphogenesis
BPIEAGO:0021670lateral ventricle development
BPIEAGO:0021987cerebral cortex development
BPIEAGO:0030534adult behavior
BPIEAGO:0035914skeletal muscle cell differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048701embryonic cranial skeleton morphogenesis
BPTASGO:0050855regulation of B cell receptor signaling pathway
BPIEAGO:0051573negative regulation of histone H3-K9 methylation
CCIDAGO:0001650fibrillar center
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0043231intracellular membrane-bounded organelle
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: PAX5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAX5


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939245RUNX1 regulates transcription of genes involved in BCR signaling
pidcmyb_pathwayC-MYB transcription factor network
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
netpathPathway_IDID
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP53ID signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD672Alectinib1
iGMDRD158NSC1415403
iGMDRD6AM-5805
iGMDRD221Tamoxifen4
iGMDRD434BMS-5369242
iGMDRD192CIL563
iGMDRD415LE-1353
iGMDRD311Dacinostat1
iGMDRD213SMR0000686503
iGMDRD367Ro 28-16753
iGMDRD67PENFLURIDOL3
iGMDRD871BRD63682
iGMDRD414MST-3123
iGMDRD147Prima-13
iGMDRD353PD03259013
iGMDRD322FK 8662
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A3
iGMDRD512nutlin 35
iGMDRD792Cetuximab1
iGMDRD347Y-399831
iGMDRD248BRD43543
iGMDRD456Crizotinib1
iGMDRD532Olaparib3
iGMDRD125BIRB-7961
iGMDRD560MK-22063
iGMDRD237ABT-7513
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD30917AAG2
iGMDRD187BRD98763
iGMDRD100Zebularine1
iGMDRD74Idarubicin2
iGMDRD730Kahalalide F3
iGMDRD577BIX012941
iGMDRD398Sepantronium4
iGMDRD780PP-303
iGMDRD690PRIMA-1MET3
iGMDRD369TGX-1153
iGMDRD268Cerulenin2
iGMDRD598QS-113
iGMDRD451Serdemetan3
iGMDRD126Tipifarnib8
iGMDRD889Compound 7d-cis1
iGMDRD579PF7503
iGMDRD425ERASTIN3
iGMDRD686PF47086711
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD793BEC (hydrochloride)3
iGMDRD163all trans Retinoic Acid3
iGMDRD394BX-7953
iGMDRD280CYTOCHALASIN B6
iGMDRD375GW-4058333

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAX5

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