RAB33B


Summary: This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAB33B, member RAS oncogene familyMIM:605950Ensembl:ENSG00000172007HGNC:HGNC:16075PA341254q31.1

GO terms in RAB33B


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000045autophagosome assembly
BPIMPGO:0001558regulation of cell growth
BPIBAGO:0006886intracellular protein transport
BPIBAGO:0006888ER to Golgi vesicle-mediated transport
BPIMPGO:0006891intra-Golgi vesicle-mediated transport
BPIEAGO:0015031protein transport
BPIBAGO:0032482Rab protein signal transduction
BPIGIGO:0034067protein localization to Golgi apparatus
BPIMPGO:0034067protein localization to Golgi apparatus
BPIMPGO:0048705skeletal system morphogenesis
BPIMPGO:0050678regulation of epithelial cell proliferation
BPIMPGO:1903358regulation of Golgi organization
BPIMPGO:1903434negative regulation of constitutive secretory pathway
BPIMPGO:2000156regulation of retrograde vesicle-mediated transport, Golgi to ER
CCIBAGO:0000139Golgi membrane
CCTASGO:0000139Golgi membrane
CCIBAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005796Golgi lumen
CCIBAGO:0012505endomembrane system
MFIBAGO:0003924GTPase activity
MFIMPGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding

Gene expression in normal tissue: RAB33B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAB33B


DatabasePathway IDPathway Des.
kegghsa04140Autophagy - animal - Homo sapiens (human)
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6811438Intra-Golgi traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8854214TBC/RABGAPs
reactomeR-HSA-8873719RAB geranylgeranylation
reactomeR-HSA-9007101Rab regulation of trafficking

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD420Leucascandrolide A2
iGMDRD772BRD47702
iGMDRD1008SR-II-138A2
iGMDRD387CHIR-990212
iGMDRD151CHM-12
iGMDRD126Tipifarnib5
iGMDRD484Pluripotin5
iGMDRD144NSC953972
iGMDRD193Fqi11
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD446LY 21832404
iGMDRD466Chaetocin3
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B8
iGMDRD297Austocystin D2
iGMDRD255SB2250025
iGMDRD138PX 121
iGMDRD513BML-2591
iGMDRD270Ciclosporin1
iGMDRD870BRD636102
iGMDRD441TW 372
iGMDRD318PAC-12
iGMDRD399Selumetinib2
iGMDRD887Compound 23 citrate3
iGMDRD730Kahalalide F3
iGMDRD188Piperlongumine4
iGMDRD356PNU-746543
iGMDRD369TGX-1152
iGMDRD512nutlin 33
iGMDRD607Ubistatin B3
iGMDRD701NVP-AUY9222
iGMDRD560MK-22062
iGMDRD116CD4371
iGMDRD351GW843682X2
iGMDRD123Isoevodiamine3
iGMDRD137Indisulam2
iGMDRD121GMX17784
iGMDRD103SN-385
iGMDRD269Purmorphamine1
iGMDRD366PI-1032
iGMDRD286Nsc 6328393
iGMDRD414MST-3126
iGMDRD322FK 8663
iGMDRD353PD03259012
iGMDRD505Pevonedistat3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAB33B

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