AKAP9
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| A-kinase anchoring protein 9 | MIM:604001 | Ensembl:ENSG00000127914 | HGNC:HGNC:379 | PA24673 | 7q21.2 |
GO terms in AKAP9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015459 | potassium channel regulator activity |
| MF | IMP | GO:0015459 | potassium channel regulator activity |
| MF | IBA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IDA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IBA | GO:0034237 | protein kinase A regulatory subunit binding |
| MF | IPI | GO:0034237 | protein kinase A regulatory subunit binding |
| MF | IPI | GO:0044325 | ion channel binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0007020 | microtubule nucleation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007194 | negative regulation of adenylate cyclase activity |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0031116 | positive regulation of microtubule polymerization |
| BP | IBA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0051602 | response to electrical stimulus |
| BP | IBA | GO:0051661 | maintenance of centrosome location |
| BP | IMP | GO:0051661 | maintenance of centrosome location |
| BP | IMP | GO:0060306 | regulation of membrane repolarization |
| BP | IBA | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization |
| BP | IMP | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization |
| BP | IMP | GO:0071320 | cellular response to cAMP |
| BP | IMP | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IMP | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| BP | IBA | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity |
| BP | IMP | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity |
| BP | IBA | GO:1903358 | regulation of Golgi organization |
| BP | IDA | GO:1903358 | regulation of Golgi organization |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005795 | Golgi stack |
| CC | IDA | GO:0005795 | Golgi stack |
| CC | IBA | GO:0005801 | cis-Golgi network |
| CC | IDA | GO:0005801 | cis-Golgi network |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0044307 | dendritic branch |
| CC | IBA | GO:0097060 | synaptic membrane |
| CC | IEA | GO:0097060 | synaptic membrane |
Gene expression in normal tissue: AKAP9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKAP9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5576890 | Phase 3 - rapid repolarisation |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576893 | Phase 2 - plateau phase |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD516 | Z-LLNle-CHO | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD562 | Navitoclax | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP9
CLASSFICATION
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