OBSCN


Summary: The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFMIM:608616Ensembl:ENSG00000154358HGNC:HGNC:15719PA318881q42.13

GO terms in OBSCN


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004674protein serine/threonine kinase activity
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005089Rho guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFNASGO:0008307structural constituent of muscle
MFIPIGO:0030506ankyrin binding
MFIPIGO:0031432titin binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0006468protein phosphorylation
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0007275multicellular organism development
BPIEAGO:0035023regulation of Rho protein signal transduction
BPISSGO:0036309protein localization to M-band
BPTASGO:0043065positive regulation of apoptotic process
BPTASGO:0045214sarcomere organization
BPTASGO:0051056regulation of small GTPase mediated signal transduction
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0016604nuclear body
CCNASGO:0030016myofibril
CCISSGO:0030018Z disc
CCISSGO:0031430M band
CCIEAGO:0042383sarcolemma

Gene expression in normal tissue: OBSCN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OBSCN


DatabasePathway IDPathway Des.
pidrhoa_reg_pathwayRegulation of RhoA activity
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-73887Death Receptor Signalling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD552AZD-17751
iGMDRD246NPC265
iGMDRD505Pevonedistat10
iGMDRD286Nsc 6328396
iGMDRD414MST-3123
iGMDRD329Merck603
iGMDRD289Parthenolide1
iGMDRD103SN-386
iGMDRD123Isoevodiamine5
iGMDRD945ML2141
iGMDRD357AG 143613
iGMDRD154NSC237665
iGMDRD435BI-25363
iGMDRD85Ursolic acid2
iGMDRD341Triacsin c2
iGMDRD698Neratinib2
iGMDRD116CD4372
iGMDRD79Gemcitabine2
iGMDRD84Lovastatin acid4
iGMDRD64Parbendazole8
iGMDRD451Serdemetan2
iGMDRD23Gossypol3
iGMDRD887Compound 23 citrate5
iGMDRD188Piperlongumine2
iGMDRD562Navitoclax3
iGMDRD888Compound 442
iGMDRD782DC-45-A23
iGMDRD187BRD98762
iGMDRD318PAC-11
iGMDRD138PX 125
iGMDRD480KU00606483
iGMDRD255SB2250028
iGMDRD260FQI-23
iGMDRD679Bistramide A3
iGMDRD297Austocystin D2
iGMDRD634SCHEMBL26080412
iGMDRD446LY 21832403
iGMDRD152179324-69-71
iGMDRD193Fqi13
iGMDRD61Kinetin riboside3
iGMDRD427ABT7372
iGMDRD779PRL-3 Inhibitor I1
iGMDRD546BMS-7548072
iGMDRD494Neopeltolide3
iGMDRD151CHM-14
iGMDRD433Lexibulin3
iGMDRD126Tipifarnib6
iGMDRD420Leucascandrolide A6
iGMDRD1008SR-II-138A3
iGMDRD599Salermide4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OBSCN

​​​​