ULK2
Summary: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:608650 Ensembl IDEnsembl:ENSG00000083290 HGNC IDHGNC:HGNC:13480 PHARMGKB IDPA37780 Map Location17p11.2 |
GO terms in ULK2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
CC | IBA | GO:0000407 | phagophore assembly site |
CC | IBA | GO:0005829 | cytosol |
Gene expression in normal tissue: ULK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ULK2
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
pid | mtor_4pathway | mTOR signaling pathway |
wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ULK2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |