COL3A1


Summary: This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
collagen type III alpha 1 chainMIM:120180Ensembl:ENSG00000168542HGNC:HGNC:2201PA267162q32.2

Gene Categories:

DRUGGABLE GENOME

GO terms in COL3A1


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005586collagen type III trimer
CCIDAGO:0005586collagen type III trimer
CCIMPGO:0005586collagen type III trimer
CCNASGO:0005586collagen type III trimer
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCNASGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCIMPGO:0031012extracellular matrix
CCHDAGO:0062023collagen-containing extracellular matrix
CCTASGO:0062023collagen-containing extracellular matrix
BPIEAGO:0001501skeletal system development
BPIDAGO:0007160cell-matrix adhesion
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPIMPGO:0007229integrin-mediated signaling pathway
BPIMPGO:0007507heart development
BPIEAGO:0007568aging
BPIDAGO:0009314response to radiation
BPIEAGO:0009612response to mechanical stimulus
BPIDAGO:0018149peptide cross-linking
BPISSGO:0021987cerebral cortex development
BPNASGO:0030168platelet activation
BPIBAGO:0030198extracellular matrix organization
BPTASGO:0030198extracellular matrix organization
BPIMPGO:0030199collagen fibril organization
BPNASGO:0030199collagen fibril organization
BPIDAGO:0034097response to cytokine
BPISSGO:0035025positive regulation of Rho protein signal transduction
BPIDAGO:0042060wound healing
BPNASGO:0042060wound healing
BPIMPGO:0043588skin development
BPIEAGO:0048565digestive tract development
BPTASGO:0050776regulation of immune response
BPIMPGO:0050777negative regulation of immune response
BPIEAGO:0060414aorta smooth muscle tissue morphogenesis
BPIEAGO:0071230cellular response to amino acid stimulus
BPIMPGO:0097435supramolecular fiber organization
BPISSGO:2001223negative regulation of neuron migration
MFIPIGO:0002020protease binding
MFIMPGO:0005178integrin binding
MFNASGO:0005178integrin binding
MFIBAGO:0005201extracellular matrix structural constituent
MFIMPGO:0005201extracellular matrix structural constituent
MFIPIGO:0005515protein binding
MFHDAGO:0030020extracellular matrix structural constituent conferring tensile strength
MFIEAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0048407platelet-derived growth factor binding

Gene expression in normal tissue: COL3A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COL3A1


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1650814Collagen biosynthesis and modifying enzymes
reactomeR-HSA-168256Immune System
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-2022090Assembly of collagen fibrils and other multimeric structures
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-2173782Binding and Uptake of Ligands by Scavenger Receptors
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-3000480Scavenging by Class A Receptors
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-8874081MET activates PTK2 signaling
reactomeR-HSA-8875878MET promotes cell motility
reactomeR-HSA-8948216Collagen chain trimerization
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2911miRNA targets in ECM and membrane receptors
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3967miR-509-3p alteration of YAP1-ECM axis
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP453Inflammatory Response Pathway
wikipathwaysWP615Senescence and Autophagy in Cancer
pharmgkbPA154444041Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidendothelinpathwayEndothelins
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04974Protein digestion and absorption - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD433Lexibulin6
iGMDRD599Salermide5
iGMDRD420Leucascandrolide A3
iGMDRD1008SR-II-138A2
iGMDRD772BRD47702
iGMDRD779PRL-3 Inhibitor I1
iGMDRD546BMS-7548072
iGMDRD494Neopeltolide4
iGMDRD718Pyrvinium pamoate1
iGMDRD193Fqi11
iGMDRD466Chaetocin1
iGMDRD394BX-7953
iGMDRD359OSW-12
iGMDRD474Avrainvillamide3
iGMDRD138PX 125
iGMDRD255SB2250021
iGMDRD782DC-45-A25
iGMDRD226ML0062
iGMDRD885Compound 1102
iGMDRD187BRD98762
iGMDRD188Piperlongumine2
iGMDRD399Selumetinib2
iGMDRD577BIX012941
iGMDRD562Navitoclax2
iGMDRD64Parbendazole1
iGMDRD524ISX-92
iGMDRD451Serdemetan2
iGMDRD330BRD41321
iGMDRD248BRD43543
iGMDRD116CD4371
iGMDRD523Cyanoquinoline, 112
iGMDRD405PIK-753
iGMDRD177Teniposide3
iGMDRD154NSC237664
iGMDRD202Curcumin6
iGMDRD158NSC1415403
iGMDRD105Triptolide1
iGMDRD434BMS-5369242
iGMDRD481Dactolisib2
iGMDRD267Oligomycin A1
iGMDRD77Itraconazole2
iGMDRD414MST-3125
iGMDRD329Merck603
iGMDRD366PI-1031
iGMDRD505Pevonedistat5
iGMDRD246NPC263

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COL3A1

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