GRIN2A


Summary: This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutamate ionotropic receptor NMDA type subunit 2AMIM:138253Ensembl:ENSG00000183454HGNC:HGNC:4585PA2897916p13.2

GO terms in GRIN2A


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIEAGO:0008021synaptic vesicle
CCISSGO:0009986cell surface
CCISSGO:0014069postsynaptic density
CCIBAGO:0017146NMDA selective glutamate receptor complex
CCIDAGO:0017146NMDA selective glutamate receptor complex
CCTASGO:0017146NMDA selective glutamate receptor complex
CCIEAGO:0030054cell junction
CCIEAGO:0042734presynaptic membrane
CCIEAGO:0043005neuron projection
CCISSGO:0097060synaptic membrane
CCIBAGO:0098839postsynaptic density membrane
CCIEAGO:0099061integral component of postsynaptic density membrane
BPTASGO:0000165MAPK cascade
BPIEAGO:0001964startle response
BPIEAGO:0001975response to amphetamine
BPTASGO:0007215glutamate receptor signaling pathway
BPTASGO:0007268chemical synaptic transmission
BPNASGO:0007420brain development
BPTASGO:0007611learning or memory
BPIEAGO:0007613memory
BPIEAGO:0008542visual learning
BPIEAGO:0009611response to wounding
BPIEAGO:0019233sensory perception of pain
BPIEAGO:0019722calcium-mediated signaling
BPIEAGO:0022008neurogenesis
BPIEAGO:0030431sleep
BPIEAGO:0033058directional locomotion
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPIEAGO:0042177negative regulation of protein catabolic process
BPIEAGO:0042417dopamine metabolic process
BPIEAGO:0042428serotonin metabolic process
BPIEAGO:0043065positive regulation of apoptotic process
BPIDAGO:0045471response to ethanol
BPNASGO:0048167regulation of synaptic plasticity
BPIEAGO:0051930regulation of sensory perception of pain
BPIBAGO:0060079excitatory postsynaptic potential
BPIEAGO:0060079excitatory postsynaptic potential
BPIBAGO:0060291long-term synaptic potentiation
BPIEAGO:0060291long-term synaptic potentiation
BPTASGO:0097202activation of cysteine-type endopeptidase activity
BPIDAGO:0097553calcium ion transmembrane import into cytosol
BPIMPGO:0097553calcium ion transmembrane import into cytosol
BPNASGO:0098976excitatory chemical synaptic transmission
BPIEAGO:1900273positive regulation of long-term synaptic potentiation
BPIEAGO:1903539protein localization to postsynaptic membrane
BPIGIGO:1904646cellular response to amyloid-beta
MFIBAGO:0004972NMDA glutamate receptor activity
MFISSGO:0004972NMDA glutamate receptor activity
MFTASGO:0004972NMDA glutamate receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIPIGO:0005515protein binding
MFISSGO:0008270zinc ion binding
MFIDAGO:0022849glutamate-gated calcium ion channel activity
MFIMPGO:0022849glutamate-gated calcium ion channel activity

Gene expression in normal tissue: GRIN2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIN2A


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442729CREB phosphorylation through the activation of CaMKII
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-442982Ras activation upon Ca2+ influx through NMDA receptor
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-8849932Synaptic adhesion-like molecules
biocartanos1pathwaynitric oxide signaling pathway
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
pidreelinpathwayReelin signaling pathway
smpdbSMP00392Benzocaine Action Pathway
smpdbSMP00393Bupivacaine Action Pathway
smpdbSMP00394Chloroprocaine Action Pathway
smpdbSMP00395Cocaine Action Pathway
smpdbSMP00396Dibucaine Action Pathway
smpdbSMP00397Levobupivacaine Action Pathway
smpdbSMP00398Lidocaine (Local Anaesthetic) Action Pathway
smpdbSMP00399Mepivacaine Action Pathway
smpdbSMP00400Oxybuprocaine Action Pathway
smpdbSMP00401Prilocaine Action Pathway
smpdbSMP00402Procaine Action Pathway
smpdbSMP00403Proparacaine Action Pathway
smpdbSMP00404Ropivacaine Action Pathway
smpdbSMP00405Codeine Action Pathway
smpdbSMP00406Morphine Action Pathway
smpdbSMP00407Heroin Action Pathway
smpdbSMP00408Methadone Action Pathway
smpdbSMP00409Oxycodone Action Pathway
smpdbSMP00410Hydromorphone Action Pathway
smpdbSMP00411Hydrocodone Action Pathway
smpdbSMP00412Oxymorphone Action Pathway
smpdbSMP00413Alfentanil Action Pathway
smpdbSMP00414Carfentanil Action Pathway
smpdbSMP00415Fentanyl Action Pathway
smpdbSMP00416Remifentanil Action Pathway
smpdbSMP00417Sufentanil Action Pathway
smpdbSMP00422Imipramine Action Pathway
smpdbSMP00423Desipramine Action Pathway
smpdbSMP00424Citalopram Action Pathway
smpdbSMP00425Escitalopram Action Pathway
smpdbSMP00426Fluoxetine Action Pathway
smpdbSMP00431Nicotine Action Pathway
smpdbSMP00624Methadone Metabolism Pathway
smpdbSMP00671Tramadol Action Action Pathway
smpdbSMP00672Propoxyphene Action Pathway
smpdbSMP00673Levorphanol Action Pathway
smpdbSMP00674Anileridine Action Pathway
smpdbSMP00675Diphenoxylate Action Pathway
smpdbSMP00676Dezocine Action Pathway
smpdbSMP00677Levomethadyl Acetate Action Action Pathway
smpdbSMP00678Methadyl Acetate Action Pathway
smpdbSMP006793-Methylthiofentanyl Action Pathway
smpdbSMP00680Dimethylthiambutene Action Pathway
smpdbSMP00681Ethylmorphine Action Pathway
smpdbSMP00683Levallorphan Action Pathway
smpdbSMP00684Buprenorphine Action Pathway
smpdbSMP00685Alvimopan Action Pathway
smpdbSMP00686Pentazocine Action Pathway
smpdbSMP00687Naltrexone Action Pathway
smpdbSMP00688Naloxone Action Pathway
smpdbSMP00689Dihydromorphine Action Pathway
smpdbSMP00690Ketobemidone Action Pathway
smpdbSMP00691Nalbuphine Action Pathway
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4222Phosphodiesterases in neuronal function
wikipathwaysWP4223Ras Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD552AZD-17752
iGMDRD505Pevonedistat5
iGMDRD886Compound 1541A3
iGMDRD300Tozasertib2
iGMDRD366PI-1032
iGMDRD872BRD71372
iGMDRD286Nsc 6328393
iGMDRD213SMR0000686503
iGMDRD415LE-1352
iGMDRD434BMS-5369246
iGMDRD105Triptolide4
iGMDRD137Indisulam3
iGMDRD251ML1623
iGMDRD271Brefeldin A1
iGMDRD177Teniposide2
iGMDRD211(1S,3R)-RSL33
iGMDRD314Tanespimycin3
iGMDRD85Ursolic acid4
iGMDRD583LDN 1931891
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD150RITA4
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 32
iGMDRD356PNU-746541
iGMDRD23Gossypol2
iGMDRD60Quinoclamine3
iGMDRD562Navitoclax5
iGMDRD577BIX012944
iGMDRD506Fedratinib1
iGMDRD887Compound 23 citrate3
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine5
iGMDRD782DC-45-A22
iGMDRD171Pemetrexed2
iGMDRD255SB2250023
iGMDRD491TAE-6841
iGMDRD375GW-4058332
iGMDRD634SCHEMBL26080415
iGMDRD466Chaetocin2
iGMDRD394BX-7951
iGMDRD280CYTOCHALASIN B4
iGMDRD71Sparfosic acid3
iGMDRD201SKI II1
iGMDRD446LY 21832401
iGMDRD781Sirolimus4
iGMDRD494Neopeltolide2
iGMDRD670ML 2102
iGMDRD889Compound 7d-cis3
iGMDRD599Salermide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIN2A

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