GRIN2A
Summary: This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor NMDA type subunit 2A | MIM:138253 | Ensembl:ENSG00000183454 | HGNC:HGNC:4585 | PA28979 | 16p13.2 |
GO terms in GRIN2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | ISS | GO:0009986 | cell surface |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | IBA | GO:0017146 | NMDA selective glutamate receptor complex |
| CC | IDA | GO:0017146 | NMDA selective glutamate receptor complex |
| CC | TAS | GO:0017146 | NMDA selective glutamate receptor complex |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0042734 | presynaptic membrane |
| CC | IEA | GO:0043005 | neuron projection |
| CC | ISS | GO:0097060 | synaptic membrane |
| CC | IBA | GO:0098839 | postsynaptic density membrane |
| CC | IEA | GO:0099061 | integral component of postsynaptic density membrane |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001964 | startle response |
| BP | IEA | GO:0001975 | response to amphetamine |
| BP | TAS | GO:0007215 | glutamate receptor signaling pathway |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | NAS | GO:0007420 | brain development |
| BP | TAS | GO:0007611 | learning or memory |
| BP | IEA | GO:0007613 | memory |
| BP | IEA | GO:0008542 | visual learning |
| BP | IEA | GO:0009611 | response to wounding |
| BP | IEA | GO:0019233 | sensory perception of pain |
| BP | IEA | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0022008 | neurogenesis |
| BP | IEA | GO:0030431 | sleep |
| BP | IEA | GO:0033058 | directional locomotion |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IEA | GO:0042177 | negative regulation of protein catabolic process |
| BP | IEA | GO:0042417 | dopamine metabolic process |
| BP | IEA | GO:0042428 | serotonin metabolic process |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0045471 | response to ethanol |
| BP | NAS | GO:0048167 | regulation of synaptic plasticity |
| BP | IEA | GO:0051930 | regulation of sensory perception of pain |
| BP | IBA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IBA | GO:0060291 | long-term synaptic potentiation |
| BP | IEA | GO:0060291 | long-term synaptic potentiation |
| BP | TAS | GO:0097202 | activation of cysteine-type endopeptidase activity |
| BP | IDA | GO:0097553 | calcium ion transmembrane import into cytosol |
| BP | IMP | GO:0097553 | calcium ion transmembrane import into cytosol |
| BP | NAS | GO:0098976 | excitatory chemical synaptic transmission |
| BP | IEA | GO:1900273 | positive regulation of long-term synaptic potentiation |
| BP | IEA | GO:1903539 | protein localization to postsynaptic membrane |
| BP | IGI | GO:1904646 | cellular response to amyloid-beta |
| MF | IBA | GO:0004972 | NMDA glutamate receptor activity |
| MF | ISS | GO:0004972 | NMDA glutamate receptor activity |
| MF | TAS | GO:0004972 | NMDA glutamate receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0022849 | glutamate-gated calcium ion channel activity |
| MF | IMP | GO:0022849 | glutamate-gated calcium ion channel activity |
Gene expression in normal tissue: GRIN2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIN2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-8849932 | Synaptic adhesion-like molecules |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05030 | Cocaine addiction - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| pid | reelinpathway | Reelin signaling pathway |
| smpdb | SMP00392 | Benzocaine Action Pathway |
| smpdb | SMP00393 | Bupivacaine Action Pathway |
| smpdb | SMP00394 | Chloroprocaine Action Pathway |
| smpdb | SMP00395 | Cocaine Action Pathway |
| smpdb | SMP00396 | Dibucaine Action Pathway |
| smpdb | SMP00397 | Levobupivacaine Action Pathway |
| smpdb | SMP00398 | Lidocaine (Local Anaesthetic) Action Pathway |
| smpdb | SMP00399 | Mepivacaine Action Pathway |
| smpdb | SMP00400 | Oxybuprocaine Action Pathway |
| smpdb | SMP00401 | Prilocaine Action Pathway |
| smpdb | SMP00402 | Procaine Action Pathway |
| smpdb | SMP00403 | Proparacaine Action Pathway |
| smpdb | SMP00404 | Ropivacaine Action Pathway |
| smpdb | SMP00405 | Codeine Action Pathway |
| smpdb | SMP00406 | Morphine Action Pathway |
| smpdb | SMP00407 | Heroin Action Pathway |
| smpdb | SMP00408 | Methadone Action Pathway |
| smpdb | SMP00409 | Oxycodone Action Pathway |
| smpdb | SMP00410 | Hydromorphone Action Pathway |
| smpdb | SMP00411 | Hydrocodone Action Pathway |
| smpdb | SMP00412 | Oxymorphone Action Pathway |
| smpdb | SMP00413 | Alfentanil Action Pathway |
| smpdb | SMP00414 | Carfentanil Action Pathway |
| smpdb | SMP00415 | Fentanyl Action Pathway |
| smpdb | SMP00416 | Remifentanil Action Pathway |
| smpdb | SMP00417 | Sufentanil Action Pathway |
| smpdb | SMP00422 | Imipramine Action Pathway |
| smpdb | SMP00423 | Desipramine Action Pathway |
| smpdb | SMP00424 | Citalopram Action Pathway |
| smpdb | SMP00425 | Escitalopram Action Pathway |
| smpdb | SMP00426 | Fluoxetine Action Pathway |
| smpdb | SMP00431 | Nicotine Action Pathway |
| smpdb | SMP00624 | Methadone Metabolism Pathway |
| smpdb | SMP00671 | Tramadol Action Action Pathway |
| smpdb | SMP00672 | Propoxyphene Action Pathway |
| smpdb | SMP00673 | Levorphanol Action Pathway |
| smpdb | SMP00674 | Anileridine Action Pathway |
| smpdb | SMP00675 | Diphenoxylate Action Pathway |
| smpdb | SMP00676 | Dezocine Action Pathway |
| smpdb | SMP00677 | Levomethadyl Acetate Action Action Pathway |
| smpdb | SMP00678 | Methadyl Acetate Action Pathway |
| smpdb | SMP00679 | 3-Methylthiofentanyl Action Pathway |
| smpdb | SMP00680 | Dimethylthiambutene Action Pathway |
| smpdb | SMP00681 | Ethylmorphine Action Pathway |
| smpdb | SMP00683 | Levallorphan Action Pathway |
| smpdb | SMP00684 | Buprenorphine Action Pathway |
| smpdb | SMP00685 | Alvimopan Action Pathway |
| smpdb | SMP00686 | Pentazocine Action Pathway |
| smpdb | SMP00687 | Naltrexone Action Pathway |
| smpdb | SMP00688 | Naloxone Action Pathway |
| smpdb | SMP00689 | Dihydromorphine Action Pathway |
| smpdb | SMP00690 | Ketobemidone Action Pathway |
| smpdb | SMP00691 | Nalbuphine Action Pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
| wikipathways | WP4223 | Ras Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD150 | RITA | 4 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD599 | Salermide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIN2A
CLASSFICATION
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