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MYH9

Summary: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
myosin heavy chain 9	MIM:160775	Ensembl:ENSG00000100345	HGNC:HGNC:7579	PA31377	22q12.3

Gene Categories:

CELL SURFACE

GO terms in MYH9

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0000212	meiotic spindle organization
BP	IDA	GO:0001525	angiogenesis
BP	IEA	GO:0001701	in utero embryonic development
BP	IEA	GO:0001768	establishment of T cell polarity
BP	IDA	GO:0006509	membrane protein ectodomain proteolysis
BP	ISS	GO:0006911	phagocytosis, engulfment
BP	IEA	GO:0007018	microtubule-based movement
BP	NAS	GO:0007229	integrin-mediated signaling pathway
BP	IEA	GO:0007520	myoblast fusion
BP	IMP	GO:0008360	regulation of cell shape
BP	IMP	GO:0015031	protein transport
BP	IDA	GO:0030048	actin filament-based movement
BP	IMP	GO:0030220	platelet formation
BP	IEP	GO:0030224	monocyte differentiation
BP	IDA	GO:0031032	actomyosin structure organization
BP	IMP	GO:0031532	actin cytoskeleton reorganization
BP	IMP	GO:0032506	cytokinetic process
BP	IEA	GO:0032796	uropod organization
BP	IMP	GO:0043534	blood vessel endothelial cell migration
BP	NAS	GO:0050900	leukocyte migration
BP	IEA	GO:0051295	establishment of meiotic spindle localization
BP	HMP	GO:0070527	platelet aggregation
BP	IMP	GO:1903919	negative regulation of actin filament severing
BP	ISS	GO:1903919	negative regulation of actin filament severing
BP	ISS	GO:1903923	positive regulation of protein processing in phagocytic vesicle
CC	IDA	GO:0001725	stress fiber
CC	IDA	GO:0001726	ruffle
CC	IDA	GO:0001772	immunological synapse
CC	IDA	GO:0001931	uropod
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IEA	GO:0005819	spindle
CC	IDA	GO:0005826	actomyosin contractile ring
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0005886	plasma membrane
CC	IEA	GO:0005903	brush border
CC	IEA	GO:0005913	cell-cell adherens junction
CC	ISS	GO:0005925	focal adhesion
CC	IDA	GO:0008180	COP9 signalosome
CC	IDA	GO:0008305	integrin complex
CC	IDA	GO:0015629	actin cytoskeleton
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0016460	myosin II complex
CC	IDA	GO:0031252	cell leading edge
CC	IEA	GO:0031594	neuromuscular junction
CC	IDA	GO:0032154	cleavage furrow
CC	IDA	GO:0032991	protein-containing complex
CC	IDA	GO:0042641	actomyosin
CC	HDA	GO:0070062	extracellular exosome
CC	IDA	GO:0097513	myosin II filament
MF	IDA	GO:0000146	microfilament motor activity
MF	HDA	GO:0003723	RNA binding
MF	NAS	GO:0003774	motor activity
MF	IEA	GO:0003777	microtubule motor activity
MF	IDA	GO:0003779	actin binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005516	calmodulin binding
MF	IDA	GO:0005524	ATP binding
MF	IEA	GO:0008017	microtubule binding
MF	IDA	GO:0016887	ATPase activity
MF	IPI	GO:0019904	protein domain specific binding
MF	IDA	GO:0030898	actin-dependent ATPase activity
MF	IDA	GO:0030898	actin-dependent ATPase activity
MF	IDA	GO:0042803	protein homodimerization activity
MF	IMP	GO:0043495	protein membrane anchor
MF	IDA	GO:0043531	ADP binding
MF	HDA	GO:0045296	cadherin binding
MF	IDA	GO:0051015	actin filament binding
MF	IDA	GO:0051015	actin filament binding
MF	NAS	GO:0051015	actin filament binding

Gene expression in normal tissue: MYH9

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYH9

Database	Pathway ID	Pathway Des.
kegg	hsa04530	Tight junction - Homo sapiens (human)
kegg	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)
kegg	hsa05132	Salmonella infection - Homo sapiens (human)
netpath	Pathway_EGFR1	EGFR1
wikipathways	WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-199991	Membrane Trafficking
reactome	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis
reactome	R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-373755	Semaphorin interactions
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-400685	Sema4D in semaphorin signaling
reactome	R-HSA-416572	Sema4D induced cell migration and growth-cone collapse
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-5625740	RHO GTPases activate PKNs
reactome	R-HSA-5625900	RHO GTPases activate CIT
reactome	R-HSA-5627117	RHO GTPases Activate ROCKs
reactome	R-HSA-5627123	RHO GTPases activate PAKs
reactome	R-HSA-5627123	RHO GTPases activate PAKs
reactome	R-HSA-5653656	Vesicle-mediated transport

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD173	Epothilone B	1
iGMDRD137	Indisulam	6
iGMDRD504	Obatoclax	1
iGMDRD481	Dactolisib	2
iGMDRD6	AM-580	2
iGMDRD705	Nakiterpiosin	3
iGMDRD192	CIL56	2
iGMDRD286	Nsc 632839	2
iGMDRD871	BRD6368	3
iGMDRD367	Ro 28-1675	2
iGMDRD505	Pevonedistat	5
iGMDRD512	nutlin 3	2
iGMDRD584	VER 155008	3
iGMDRD486	Tosedostat	2
iGMDRD523	Cyanoquinoline, 11	1
iGMDRD652	UNC0638	2
iGMDRD560	MK-2206	1
iGMDRD532	Olaparib	2
iGMDRD522	ML-030	1
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD237	ABT-751	3
iGMDRD341	Triacsin c	3
iGMDRD85	Ursolic acid	2
iGMDRD292	NSC87877	1
iGMDRD435	BI-2536	7
iGMDRD132	(-)-gallocatechin-3-O-gallate	4
iGMDRD511	CHEMBL399379	1
iGMDRD123	Isoevodiamine	1
iGMDRD177	Teniposide	6
iGMDRD255	SB225002	2
iGMDRD260	FQI-2	1
iGMDRD138	PX 12	3
iGMDRD294	Batimastat	1
iGMDRD171	Pemetrexed	1
iGMDRD577	BIX01294	4
iGMDRD780	PP-30	4
iGMDRD562	Navitoclax	6
iGMDRD524	ISX-9	2
iGMDRD64	Parbendazole	4
iGMDRD60	Quinoclamine	1
iGMDRD889	Compound 7d-cis	2
iGMDRD420	Leucascandrolide A	4
iGMDRD151	CHM-1	7
iGMDRD283	Bosutinib	1
iGMDRD494	Neopeltolide	2
iGMDRD781	Sirolimus	4
iGMDRD670	ML 210	7
iGMDRD427	ABT737	5
iGMDRD639	YK 4-279	3
iGMDRD193	Fqi1	7
iGMDRD446	LY 2183240	4
iGMDRD201	SKI II	1
iGMDRD634	SCHEMBL2608041	5
iGMDRD394	BX-795	4
iGMDRD280	CYTOCHALASIN B	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYH9

SITE

DATATYPES

CLASSFICATION

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