TRIP11


Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thyroid hormone receptor interactor 11MIM:604505Ensembl:ENSG00000100815HGNC:HGNC:12305PA3698414q32.12

GO terms in TRIP11


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0000139Golgi membrane
CCIEAGO:0002079inner acrosomal membrane
CCIEAGO:0002081outer acrosomal membrane
CCIDAGO:0005634nucleus
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005801cis-Golgi network
CCIEAGO:0005856cytoskeleton
CCIEAGO:0005929cilium
CCIDAGO:0016607nuclear speck
CCTASGO:0030133transport vesicle
BPIEAGO:0003281ventricular septum development
BPIEAGO:0003413chondrocyte differentiation involved in endochondral bone morphogenesis
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0006486protein glycosylation
BPIEAGO:0007030Golgi organization
BPTASGO:0035735intraciliary transport involved in cilium assembly
BPIEAGO:0060122inner ear receptor cell stereocilium organization
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
MFTASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: TRIP11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIP11


DatabasePathway IDPathway Des.
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620924Intraflagellar transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6811438Intra-Golgi traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1
iGMDRD64Parbendazole6
iGMDRD524ISX-92
iGMDRD356PNU-746542
iGMDRD100Zebularine2
iGMDRD188Piperlongumine2
iGMDRD562Navitoclax6
iGMDRD187BRD98763
iGMDRD318PAC-11
iGMDRD474Avrainvillamide1
iGMDRD260FQI-22
iGMDRD8024-methylfasudil6
iGMDRD280CYTOCHALASIN B2
iGMDRD466Chaetocin3
iGMDRD634SCHEMBL26080412
iGMDRD446LY 21832404
iGMDRD61Kinetin riboside2
iGMDRD193Fqi14
iGMDRD718Pyrvinium pamoate1
iGMDRD427ABT7371
iGMDRD483SCH-5290743
iGMDRD494Neopeltolide3
iGMDRD151CHM-13
iGMDRD1008SR-II-138A2
iGMDRD889Compound 7d-cis3
iGMDRD552AZD-17752
iGMDRD505Pevonedistat7
iGMDRD871BRD63682
iGMDRD414MST-3123
iGMDRD329Merck602
iGMDRD434BMS-5369243
iGMDRD705Nakiterpiosin2
iGMDRD77Itraconazole4
iGMDRD415LE-1352
iGMDRD137Indisulam7
iGMDRD158NSC1415401
iGMDRD121GMX17782
iGMDRD202Curcumin1
iGMDRD227Fatostatin A6
iGMDRD177Teniposide4
iGMDRD123Isoevodiamine5
iGMDRD237ABT-7513
iGMDRD351GW843682X3
iGMDRD314Tanespimycin2
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD150RITA5
iGMDRD79Gemcitabine4
iGMDRD405PIK-756
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIP11

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