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WNK2

Summary: The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
WNK lysine deficient protein kinase 2	MIM:606249	Ensembl:ENSG00000165238	HGNC:HGNC:14542	PA33783	9q22.31

Gene Categories:

SERINE THREONINE KINASE KINASE TRANSPORTER DRUGGABLE GENOME

GO terms in WNK2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005737	cytoplasm
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	IEA	GO:0005886	plasma membrane
BP	IBA	GO:0006468	protein phosphorylation
BP	IDA	GO:0006468	protein phosphorylation
BP	IMP	GO:0008285	negative regulation of cell proliferation
BP	IBA	GO:0032414	positive regulation of ion transmembrane transporter activity
BP	IBA	GO:0035556	intracellular signal transduction
BP	ISS	GO:0035556	intracellular signal transduction
BP	IDA	GO:0046777	protein autophosphorylation
BP	IMP	GO:0050801	ion homeostasis
BP	IMP	GO:0070373	negative regulation of ERK1 and ERK2 cascade
BP	IMP	GO:0090263	positive regulation of canonical Wnt signaling pathway
BP	IBA	GO:2000651	positive regulation of sodium ion transmembrane transporter activity
BP	IMP	GO:2000651	positive regulation of sodium ion transmembrane transporter activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	ISS	GO:0004674	protein serine/threonine kinase activity
MF	ISS	GO:0005524	ATP binding

Gene expression in normal tissue: WNK2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WNK2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2672351	Stimuli-sensing channels
reactome	R-HSA-382551	Transport of small molecules
reactome	R-HSA-983712	Ion channel transport

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD286	Nsc 632839	5
iGMDRD366	PI-103	3
iGMDRD662	JQ-1	2
iGMDRD329	Merck60	2
iGMDRD300	Tozasertib	4
iGMDRD82	Quiflapon	3
iGMDRD158	NSC141540	3
iGMDRD137	Indisulam	3
iGMDRD121	GMX1778	2
iGMDRD202	Curcumin	3
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD221	Tamoxifen	3
iGMDRD289	Parthenolide	3
iGMDRD105	Triptolide	6
iGMDRD267	Oligomycin A	2
iGMDRD85	Ursolic acid	1
iGMDRD499	PDMP	3
iGMDRD698	Neratinib	1
iGMDRD177	Teniposide	2
iGMDRD211	(1S,3R)-RSL3	1
iGMDRD132	(-)-gallocatechin-3-O-gallate	3
iGMDRD945	ML214	2
iGMDRD883	CIL55A	2
iGMDRD512	nutlin 3	2
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD150	RITA	1
iGMDRD560	MK-2206	3
iGMDRD532	Olaparib	2
iGMDRD583	LDN 193189	2
iGMDRD188	Piperlongumine	4
iGMDRD398	Sepantronium	2
iGMDRD562	Navitoclax	2
iGMDRD577	BIX01294	2
iGMDRD524	ISX-9	3
iGMDRD474	Avrainvillamide	2
iGMDRD138	PX 12	3
iGMDRD255	SB225002	4
iGMDRD782	DC-45-A2	3
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD446	LY 2183240	2
iGMDRD61	Kinetin riboside	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD634	SCHEMBL2608041	3
iGMDRD151	CHM-1	2
iGMDRD76	Simvastatin	2
iGMDRD126	Tipifarnib	2
iGMDRD772	BRD4770	6
iGMDRD144	NSC95397	2
iGMDRD670	ML 210	4
iGMDRD427	ABT737	2
iGMDRD494	Neopeltolide	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WNK2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.