ADAM17
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 17 | MIM:603639 | Ensembl:ENSG00000151694 | HGNC:HGNC:195 | PA24512 | 2p25.1 |
GO terms in ADAM17
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IC | GO:0002446 | neutrophil mediated immunity |
| BP | ISS | GO:0002467 | germinal center formation |
| BP | IC | GO:0002690 | positive regulation of leukocyte chemotaxis |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IDA | GO:0006509 | membrane protein ectodomain proteolysis |
| BP | IMP | GO:0006509 | membrane protein ectodomain proteolysis |
| BP | IDA | GO:0007155 | cell adhesion |
| BP | IDA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IDA | GO:0007220 | Notch receptor processing |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010820 | positive regulation of T cell chemotaxis |
| BP | ISS | GO:0030183 | B cell differentiation |
| BP | IMP | GO:0030307 | positive regulation of cell growth |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0031293 | membrane protein intracellular domain proteolysis |
| BP | IDA | GO:0031659 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0032496 | response to lipopolysaccharide |
| BP | IMP | GO:0032722 | positive regulation of chemokine production |
| BP | ISS | GO:0033025 | regulation of mast cell apoptotic process |
| BP | ISS | GO:0033077 | T cell differentiation in thymus |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IEP | GO:0035313 | wound healing, spreading of epidermal cells |
| BP | ISS | GO:0042493 | response to drug |
| BP | IDA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IDA | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | IMP | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | ISS | GO:0048536 | spleen development |
| BP | ISS | GO:0048870 | cell motility |
| BP | IMP | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IDA | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis |
| BP | IMP | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis |
| BP | ISS | GO:0051272 | positive regulation of cellular component movement |
| BP | IDA | GO:0071403 | cellular response to high density lipoprotein particle stimulus |
| BP | IMP | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0045121 | membrane raft |
| MF | IDA | GO:0004222 | metalloendopeptidase activity |
| MF | IMP | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | IDA | GO:0005112 | Notch binding |
| MF | IPI | GO:0005138 | interleukin-6 receptor binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | IMP | GO:0008237 | metallopeptidase activity |
| MF | TAS | GO:0008237 | metallopeptidase activity |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IPI | GO:0030165 | PDZ domain binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ADAM17
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM17
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-193692 | Regulated proteolysis of p75NTR |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-5358346 | Hedgehog ligand biogenesis |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5362798 | Release of Hh-Np from the secreting cell |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| biocarta | erbb4pathway | g-secretase mediated erbb4 signaling pathway |
| biocarta | hespathway | segmentation clock |
| biocarta | notchpathway | proteolysis and signaling pathway of notch |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD367 | Ro 28-1675 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD307 | Manumycin A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM17
CLASSFICATION
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