CYFIP1
Summary: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytoplasmic FMR1 interacting protein 1 | MIM:606322 | Ensembl:ENSG00000273749 | HGNC:HGNC:13759 | PA38367 | 15q11.2 |
GO terms in CYFIP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000340 | RNA 7-methylguanosine cap binding |
| MF | IEA | GO:0000340 | RNA 7-methylguanosine cap binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IMP | GO:0044877 | protein-containing complex binding |
| MF | IMP | GO:0048365 | Rac GTPase binding |
| MF | ISS | GO:0048365 | Rac GTPase binding |
| MF | ISS | GO:0051015 | actin filament binding |
| BP | IBA | GO:0000902 | cell morphogenesis |
| BP | IBA | GO:0006417 | regulation of translation |
| BP | IEA | GO:0006417 | regulation of translation |
| BP | IBA | GO:0007411 | axon guidance |
| BP | IEA | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0016601 | Rac protein signal transduction |
| BP | IBA | GO:0030031 | cell projection assembly |
| BP | IBA | GO:0030032 | lamellipodium assembly |
| BP | ISS | GO:0030032 | lamellipodium assembly |
| BP | ISS | GO:0031529 | ruffle organization |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0048675 | axon extension |
| BP | IMP | GO:0050890 | cognition |
| BP | IEA | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway |
| BP | IEA | GO:0051602 | response to electrical stimulus |
| BP | IEA | GO:0097484 | dendrite extension |
| BP | IBA | GO:0099563 | modification of synaptic structure |
| BP | IEA | GO:0099563 | modification of synaptic structure |
| BP | IEA | GO:1900006 | positive regulation of dendrite development |
| BP | IEA | GO:1900029 | positive regulation of ruffle assembly |
| BP | IEA | GO:1903422 | negative regulation of synaptic vesicle recycling |
| BP | IMP | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| CC | ISS | GO:0001726 | ruffle |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005845 | mRNA cap binding complex |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | IBA | GO:0031209 | SCAR complex |
| CC | IMP | GO:0031209 | SCAR complex |
| CC | IEA | GO:0032433 | filopodium tip |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0043005 | neuron projection |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043195 | terminal bouton |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IEA | GO:0044294 | dendritic growth cone |
| CC | IEA | GO:0044295 | axonal growth cone |
| CC | IBA | GO:0045202 | synapse |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0060076 | excitatory synapse |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0090724 | central region of growth cone |
| CC | IEA | GO:0090725 | peripheral region of growth cone |
| CC | TAS | GO:1904724 | tertiary granule lumen |
Gene expression in normal tissue: CYFIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYFIP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TCR | TCR |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| wikipathways | WP524 | G13 Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD263 | AACOCF3 | 4 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD67 | PENFLURIDOL | 8 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYFIP1
CLASSFICATION
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