PTPRT
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type T | MIM:608712 | Ensembl:ENSG00000196090 | HGNC:HGNC:9682 | PA34027 | 20q12-q13.11 |
GO terms in PTPRT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IDA | GO:0045294 | alpha-catenin binding |
| MF | IDA | GO:0045295 | gamma-catenin binding |
| MF | IPI | GO:0045296 | cadherin binding |
| MF | IPI | GO:0070097 | delta-catenin binding |
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | NAS | GO:0007155 | cell adhesion |
| BP | IDA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | NAS | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: PTPRT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRT
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD294 | Batimastat | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD266 | Cucurbitacin I | 1 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD139 | Fumagillol | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD329 | Merck60 | 8 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD150 | RITA | 4 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD223 | Stattic | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRT
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