CNTRL
Summary: This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| centriolin | MIM:605496 | Ensembl:ENSG00000119397 | HGNC:HGNC:1858 | PA26414 | 9q33.2 |
GO terms in CNTRL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0090543 | Flemming body |
| CC | IDA | GO:0120103 | centriolar subdistal appendage |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
Gene expression in normal tissue: CNTRL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNTRL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD226 | ML006 | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD480 | KU0060648 | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD670 | ML 210 | 4 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD446 | LY 2183240 | 10 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD202 | Curcumin | 9 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 4 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD237 | ABT-751 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNTRL
CLASSFICATION
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