EIF2AK3


Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
eukaryotic translation initiation factor 2 alpha kinase 3MIM:604032Ensembl:ENSG00000172071HGNC:HGNC:3255PA276872p11.2

GO terms in EIF2AK3


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001501skeletal system development
BPIMPGO:0001503ossification
BPIMPGO:0001525angiogenesis
BPISSGO:0002063chondrocyte development
BPISSGO:0006468protein phosphorylation
BPISSGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0006983ER overload response
BPISSGO:0007029endoplasmic reticulum organization
BPIMPGO:0010575positive regulation of vascular endothelial growth factor production
BPIMPGO:0010628positive regulation of gene expression
BPISSGO:0010998regulation of translational initiation by eIF2 alpha phosphorylation
BPTASGO:0017148negative regulation of translation
BPISSGO:0018105peptidyl-serine phosphorylation
BPISSGO:0019722calcium-mediated signaling
BPISSGO:0030282bone mineralization
BPIDAGO:0030968endoplasmic reticulum unfolded protein response
BPTASGO:0030968endoplasmic reticulum unfolded protein response
BPIMPGO:0031018endocrine pancreas development
BPISSGO:0031642negative regulation of myelination
BPTASGO:0032057negative regulation of translational initiation in response to stress
BPIMPGO:0034198cellular response to amino acid starvation
BPIMPGO:0034976response to endoplasmic reticulum stress
BPIMPGO:0036492eiF2alpha phosphorylation in response to endoplasmic reticulum stress
BPTASGO:0036492eiF2alpha phosphorylation in response to endoplasmic reticulum stress
BPTASGO:0036499PERK-mediated unfolded protein response
BPIMPGO:0042149cellular response to glucose starvation
BPIMPGO:0045943positive regulation of transcription by RNA polymerase I
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0046777protein autophosphorylation
BPISSGO:0048009insulin-like growth factor receptor signaling pathway
BPIMPGO:0051260protein homooligomerization
BPISSGO:0060734regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
BPIMPGO:0070417cellular response to cold
BPISSGO:1900182positive regulation of protein localization to nucleus
BPIMPGO:1902235regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPIEAGO:1990737response to manganese-induced endoplasmic reticulum stress
CCISSGO:0005737cytoplasm
CCICGO:0005783endoplasmic reticulum
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005783endoplasmic reticulum
CCISSGO:0005789endoplasmic reticulum membrane
CCNASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCHDAGO:0016020membrane
CCIBAGO:0022626cytosolic ribosome
CCNASGO:0030176integral component of endoplasmic reticulum membrane
CCIEAGO:0048471perinuclear region of cytoplasm
MFIBAGO:0004672protein kinase activity
MFTASGO:0004672protein kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIDAGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIMPGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019903protein phosphatase binding
MFIPIGO:0042802identical protein binding
MFTASGO:0042803protein homodimerization activity
MFIEAGO:0051879Hsp90 protein binding

Gene expression in normal tissue: EIF2AK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF2AK3


DatabasePathway IDPathway Des.
reactomeR-HSA-381042PERK regulates gene expression
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
biocartaeif2pathwayregulation of eif2
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
wikipathwaysWP107Translation Factors
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832404
iGMDRD152179324-69-73
iGMDRD193Fqi15
iGMDRD380Pifithrin-alpha2
iGMDRD387CHIR-990211
iGMDRD772BRD47702
iGMDRD427ABT7371
iGMDRD144NSC953976
iGMDRD188Piperlongumine6
iGMDRD577BIX012947
iGMDRD224Necrostatin-12
iGMDRD506Fedratinib2
iGMDRD398Sepantronium2
iGMDRD64Parbendazole4
iGMDRD23Gossypol2
iGMDRD524ISX-92
iGMDRD138PX 124
iGMDRD474Avrainvillamide1
iGMDRD8024-methylfasudil2
iGMDRD260FQI-23
iGMDRD782DC-45-A22
iGMDRD318PAC-16
iGMDRD870BRD636102
iGMDRD52Rotenone2
iGMDRD341Triacsin c2
iGMDRD698Neratinib2
iGMDRD351GW843682X2
iGMDRD219Bax channel blocker3
iGMDRD123Isoevodiamine2
iGMDRD883CIL55A2
iGMDRD945ML2145
iGMDRD154NSC237662
iGMDRD84Lovastatin acid2
iGMDRD486Tosedostat2
iGMDRD607Ubistatin B1
iGMDRD150RITA3
iGMDRD424Tamatinib2
iGMDRD79Gemcitabine3
iGMDRD701NVP-AUY9222
iGMDRD67PENFLURIDOL3
iGMDRD286Nsc 6328394
iGMDRD329Merck605
iGMDRD366PI-1031
iGMDRD269Purmorphamine2
iGMDRD505Pevonedistat4
iGMDRD246NPC262
iGMDRD353PD03259011
iGMDRD322FK 8662
iGMDRD158NSC1415403
iGMDRD202Curcumin2
iGMDRD137Indisulam6
iGMDRD251ML1624
iGMDRD289Parthenolide3
iGMDRD105Triptolide2
iGMDRD705Nakiterpiosin3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF2AK3

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