LATS1


Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
large tumor suppressor kinase 1MIM:603473Ensembl:ENSG00000131023HGNC:HGNC:6514PA303016q25.1

GO terms in LATS1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0030331estrogen receptor binding
BPIBAGO:0000082G1/S transition of mitotic cell cycle
BPIDAGO:0000086G2/M transition of mitotic cell cycle
BPIDAGO:0000819sister chromatid segregation
BPIEAGO:0001827inner cell mass cell fate commitment
BPIEAGO:0001828inner cell mass cellular morphogenesis
BPIDAGO:0006468protein phosphorylation
BPISSGO:0009755hormone-mediated signaling pathway
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0030216keratinocyte differentiation
BPIDAGO:0030833regulation of actin filament polymerization
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIMPGO:0033146regulation of intracellular estrogen receptor signaling pathway
BPIEAGO:0034613cellular protein localization
BPIBAGO:0035329hippo signaling
BPIDAGO:0035329hippo signaling
BPTASGO:0035329hippo signaling
BPIBAGO:0035556intracellular signal transduction
BPIBAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043254regulation of protein complex assembly
BPIDAGO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0046620regulation of organ growth
BPIMPGO:0051220cytoplasmic sequestering of protein
BPIEAGO:0051301cell division
BPIMPGO:0060644mammary gland epithelial cell differentiation
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPIMPGO:2000058regulation of ubiquitin-dependent protein catabolic process
CCIBAGO:0000922spindle pole
CCIDAGO:0000922spindle pole
CCIEAGO:0005815microtubule organizing center
CCTASGO:0005829cytosol

Gene expression in normal tissue: LATS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LATS1


DatabasePathway IDPathway Des.
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04392Hippo signaling pathway - multiple species - Homo sapiens (human)
wikipathwaysWP2857Mesodermal Commitment Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2028269Signaling by Hippo

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD779PRL-3 Inhibitor I1
iGMDRD427ABT7371
iGMDRD546BMS-7548073
iGMDRD781Sirolimus2
iGMDRD126Tipifarnib4
iGMDRD1008SR-II-138A3
iGMDRD889Compound 7d-cis2
iGMDRD387CHIR-990212
iGMDRD599Salermide2
iGMDRD280CYTOCHALASIN B2
iGMDRD297Austocystin D1
iGMDRD446LY 21832404
iGMDRD152179324-69-71
iGMDRD294Batimastat1
iGMDRD318PAC-12
iGMDRD270Ciclosporin4
iGMDRD64Parbendazole3
iGMDRD640CAY106181
iGMDRD451Serdemetan3
iGMDRD356PNU-746541
iGMDRD268Cerulenin3
iGMDRD399Selumetinib2
iGMDRD100Zebularine2
iGMDRD188Piperlongumine5
iGMDRD780PP-302
iGMDRD506Fedratinib2
iGMDRD424Tamatinib3
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD150RITA2
iGMDRD79Gemcitabine3
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2
iGMDRD123Isoevodiamine1
iGMDRD901ELCPK2
iGMDRD945ML2142
iGMDRD511CHEMBL3993792
iGMDRD237ABT-7513
iGMDRD105Triptolide2
iGMDRD6AM-5804
iGMDRD137Indisulam2
iGMDRD121GMX17783
iGMDRD202Curcumin2
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat9
iGMDRD322FK 8663
iGMDRD67PENFLURIDOL3
iGMDRD871BRD63682
iGMDRD286Nsc 6328394
iGMDRD414MST-3124
iGMDRD366PI-1033

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LATS1

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