MINK1


Summary: This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
misshapen like kinase 1MIM:609426Ensembl:ENSG00000141503HGNC:HGNC:17565PA13491064117p13.2

GO terms in MINK1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFISSGO:0005524ATP binding
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIEAGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCIEAGO:0030424axon
CCIEAGO:0030425dendrite
CCIEAGO:0045211postsynaptic membrane
CCHDAGO:0070062extracellular exosome
BPIBAGO:0000165MAPK cascade
BPIEAGO:0000185activation of MAPKKK activity
BPIMPGO:0001952regulation of cell-matrix adhesion
BPIMPGO:0006468protein phosphorylation
BPISSGO:0006468protein phosphorylation
BPTASGO:0007254JNK cascade
BPISSGO:0007268chemical synaptic transmission
BPISSGO:0007275multicellular organism development
BPIBAGO:0007346regulation of mitotic cell cycle
BPIMPGO:0022407regulation of cell-cell adhesion
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIMPGO:0030033microvillus assembly
BPIMPGO:0030334regulation of cell migration
BPIBAGO:0031532actin cytoskeleton reorganization
BPIMPGO:0031532actin cytoskeleton reorganization
BPIBAGO:0032147activation of protein kinase activity
BPIMPGO:0046330positive regulation of JNK cascade
BPISSGO:0046330positive regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation
BPIBAGO:0048812neuron projection morphogenesis
BPISSGO:0048813dendrite morphogenesis
BPISSGO:1900745positive regulation of p38MAPK cascade
BPISSGO:2000311regulation of AMPA receptor activity

Gene expression in normal tissue: MINK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MINK1


DatabasePathway IDPathway Des.
wikipathwaysWP3404Oxidative Stress Induced Senescence
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
netpathPathway_EGFR1EGFR1
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD268Cerulenin6
iGMDRD23Gossypol9
iGMDRD524ISX-94
iGMDRD444Tivantinib2
iGMDRD888Compound 445
iGMDRD506Fedratinib2
iGMDRD562Navitoclax6
iGMDRD780PP-303
iGMDRD188Piperlongumine6
iGMDRD441TW 373
iGMDRD885Compound 1101
iGMDRD318PAC-11
iGMDRD255SB2250023
iGMDRD138PX 123
iGMDRD634SCHEMBL26080415
iGMDRD297Austocystin D2
iGMDRD446LY 21832406
iGMDRD201SKI II7
iGMDRD427ABT7376
iGMDRD889Compound 7d-cis5
iGMDRD1008SR-II-138A6
iGMDRD554CHEMBL14341373
iGMDRD42Vorinostat1
iGMDRD147Prima-14
iGMDRD414MST-3123
iGMDRD882CIL413
iGMDRD872BRD71373
iGMDRD77Itraconazole1
iGMDRD213SMR0000686503
iGMDRD289Parthenolide6
iGMDRD6AM-5802
iGMDRD434BMS-5369245
iGMDRD103SN-382
iGMDRD202Curcumin2
iGMDRD137Indisulam5
iGMDRD511CHEMBL3993793
iGMDRD945ML2145
iGMDRD123Isoevodiamine2
iGMDRD351GW843682X5
iGMDRD701NVP-AUY9222
iGMDRD150RITA3
iGMDRD424Tamatinib3
iGMDRD512nutlin 31
iGMDRD148Pifithrin-mu3
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MINK1

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