ROCK1


Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rho associated coiled-coil containing protein kinase 1MIM:601702Ensembl:ENSG00000067900HGNC:HGNC:10251PA3462318q11.1

GO terms in ROCK1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004672protein kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0017049GTP-Rho binding
MFIEAGO:0046872metal ion binding
CCIEAGO:0000139Golgi membrane
CCISSGO:0001726ruffle
CCTASGO:0005576extracellular region
CCIEAGO:0005814centriole
CCTASGO:0005829cytosol
CCISSGO:0005856cytoskeleton
CCISSGO:0005886plasma membrane
CCISSGO:0010494cytoplasmic stress granule
CCISSGO:0030027lamellipodium
CCIEAGO:0032059bleb
CCTASGO:0034774secretory granule lumen
CCIDAGO:0106003amyloid-beta complex
BPIEAGO:0003383apical constriction
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0006915apoptotic process
BPTASGO:0006939smooth muscle contraction
BPIDAGO:0007159leukocyte cell-cell adhesion
BPTASGO:0007165signal transduction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIMPGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIGIGO:0007266Rho protein signal transduction
BPTASGO:0010506regulation of autophagy
BPIGIGO:0010508positive regulation of autophagy
BPIMPGO:0010613positive regulation of cardiac muscle hypertrophy
BPIMPGO:0010628positive regulation of gene expression
BPISSGO:0010628positive regulation of gene expression
BPIMPGO:0016525negative regulation of angiogenesis
BPIDAGO:0022614membrane to membrane docking
BPTASGO:0030036actin cytoskeleton organization
BPTASGO:0030155regulation of cell adhesion
BPIGIGO:0030866cortical actin cytoskeleton organization
BPIMPGO:0030866cortical actin cytoskeleton organization
BPIGIGO:0031175neuron projection development
BPIEAGO:0032060bleb assembly
BPIDAGO:0032091negative regulation of protein binding
BPIDAGO:0032956regulation of actin cytoskeleton organization
BPTASGO:0032956regulation of actin cytoskeleton organization
BPIGIGO:0035509negative regulation of myosin-light-chain-phosphatase activity
BPIMPGO:0035509negative regulation of myosin-light-chain-phosphatase activity
BPTASGO:0043312neutrophil degranulation
BPIMPGO:0043410positive regulation of MAPK cascade
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIMPGO:0045616regulation of keratinocyte differentiation
BPIGIGO:0045664regulation of neuron differentiation
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPIDAGO:0050900leukocyte migration
BPIDAGO:0050901leukocyte tethering or rolling
BPTASGO:0051045negative regulation of membrane protein ectodomain proteolysis
BPISSGO:0051451myoblast migration
BPTASGO:0051492regulation of stress fiber assembly
BPTASGO:0051893regulation of focal adhesion assembly
BPISSGO:0051894positive regulation of focal adhesion assembly
BPISSGO:0070168negative regulation of biomineral tissue development
BPISSGO:0071559response to transforming growth factor beta
BPIGIGO:0072659protein localization to plasma membrane
BPIMPGO:0072659protein localization to plasma membrane
BPIMPGO:0110061regulation of angiotensin-activated signaling pathway
BPIGIGO:0140058neuron projection arborization
BPIGIGO:1900223positive regulation of amyloid-beta clearance
BPIGIGO:1900242regulation of synaptic vesicle endocytosis
BPTASGO:1902003regulation of amyloid-beta formation
BPIMPGO:1902430negative regulation of amyloid-beta formation
BPIMPGO:1902992negative regulation of amyloid precursor protein catabolic process
BPIGIGO:1903140regulation of establishment of endothelial barrier
BPIMPGO:1903140regulation of establishment of endothelial barrier
BPIGIGO:1903347negative regulation of bicellular tight junction assembly
BPIMPGO:1905205positive regulation of connective tissue replacement
BPISSGO:1990776response to angiotensin
BPTASGO:2000114regulation of establishment of cell polarity
BPTASGO:2000145regulation of cell motility

Gene expression in normal tissue: ROCK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ROCK1


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP2272Pathogenic Escherichia coli infection
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP306Focal Adhesion
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP524G13 Signaling Pathway
netpathPathway_RAGERAGE
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidepha_fwdpathwayEPHA forward signaling
pidephbfwdpathwayEPHB forward signaling
pidncadherinpathwayN-cadherin signaling events
pidprlsignalingeventspathwaySignaling events mediated by PRL
pidrhoa_pathwayRhoA signaling pathway
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidthrombin_par4_pathwayPAR4-mediated thrombin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaintegrinpathwayintegrin signaling pathway
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartamyosinpathwaypkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
biocartapar1pathwaythrombin signaling and protease-activated receptors
biocartarhopathwayrho cell motility signaling pathway
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-400685Sema4D in semaphorin signaling
reactomeR-HSA-400685Sema4D in semaphorin signaling
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapse
reactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapse
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5627117RHO GTPases Activate ROCKs
reactomeR-HSA-5627117RHO GTPases Activate ROCKs
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-75153Apoptotic execution phase
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B8
iGMDRD375GW-4058333
iGMDRD639YK 4-2793
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD61Kinetin riboside2
iGMDRD163all trans Retinoic Acid3
iGMDRD793BEC (hydrochloride)3
iGMDRD152179324-69-73
iGMDRD144NSC953972
iGMDRD126Tipifarnib8
iGMDRD151CHM-12
iGMDRD889Compound 7d-cis1
iGMDRD579PF7503
iGMDRD425ERASTIN3
iGMDRD690PRIMA-1MET3
iGMDRD369TGX-1153
iGMDRD268Cerulenin2
iGMDRD598QS-113
iGMDRD23Gossypol1
iGMDRD451Serdemetan2
iGMDRD100Zebularine1
iGMDRD74Idarubicin2
iGMDRD730Kahalalide F3
iGMDRD506Fedratinib2
iGMDRD577BIX012942
iGMDRD398Sepantronium5
iGMDRD562Navitoclax2
iGMDRD780PP-303
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD318PAC-13
iGMDRD187BRD98763
iGMDRD260FQI-21
iGMDRD57Chloropentafluorobenzene6
iGMDRD560MK-22063
iGMDRD532Olaparib3
iGMDRD84Lovastatin acid3
iGMDRD307Manumycin A3
iGMDRD248BRD43543
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib2
iGMDRD147Prima-13
iGMDRD286Nsc 6328392
iGMDRD367Ro 28-16753
iGMDRD221Tamoxifen3
iGMDRD6AM-5803
iGMDRD192CIL563
iGMDRD415LE-1353
iGMDRD77Itraconazole2
iGMDRD213SMR0000686503
iGMDRD5Tyrphostin AG 14782

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ROCK1

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