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CACNB2

Summary: This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
calcium voltage-gated channel auxiliary subunit beta 2	MIM:600003	Ensembl:ENSG00000165995	HGNC:HGNC:1402	PA88	10p12.33-p12.31

Gene Categories:

DRUGGABLE GENOME TRANSPORTER ION CHANNEL

GO terms in CACNB2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005886	plasma membrane
CC	NAS	GO:0005887	integral component of plasma membrane
CC	IBA	GO:0005891	voltage-gated calcium channel complex
CC	IDA	GO:0005891	voltage-gated calcium channel complex
CC	IDA	GO:1990454	L-type voltage-gated calcium channel complex
BP	IBA	GO:0007268	chemical synaptic transmission
BP	IBA	GO:0007528	neuromuscular junction development
BP	TAS	GO:0007528	neuromuscular junction development
BP	IEA	GO:0007601	visual perception
BP	IDA	GO:0051928	positive regulation of calcium ion transport
BP	IDA	GO:0070509	calcium ion import
BP	IEA	GO:0070588	calcium ion transmembrane transport
BP	ISS	GO:0072659	protein localization to plasma membrane
BP	IMP	GO:0086045	membrane depolarization during AV node cell action potential
BP	IMP	GO:0086091	regulation of heart rate by cardiac conduction
BP	IMP	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential
BP	IBA	GO:1901385	regulation of voltage-gated calcium channel activity
BP	ISS	GO:1901843	positive regulation of high voltage-gated calcium channel activity
BP	ISS	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
MF	IDA	GO:0005245	voltage-gated calcium channel activity
MF	NAS	GO:0005262	calcium channel activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008331	high voltage-gated calcium channel activity
MF	IDA	GO:0008331	high voltage-gated calcium channel activity
MF	ISS	GO:0051015	actin filament binding
MF	IMP	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential
MF	IMP	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential

Gene expression in normal tissue: CACNB2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CACNB2

Database	Pathway ID	Pathway Des.
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04260	Cardiac muscle contraction - Homo sapiens (human)
kegg	hsa04261	Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegg	hsa04921	Oxytocin signaling pathway - Homo sapiens (human)
kegg	hsa05410	Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegg	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegg	hsa05414	Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pharmgkb	PA152241951	Celecoxib Pathway, Pharmacodynamics
pharmgkb	PA2033	Antiarrhythmic Pathway, Pharmacodynamics
wikipathways	WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways	WP382	MAPK Signaling Pathway
reactome	R-HSA-112308	Presynaptic depolarization and calcium channel opening
reactome	R-HSA-112315	Transmission across Chemical Synapses
reactome	R-HSA-112316	Neuronal System
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-163685	Integration of energy metabolism
reactome	R-HSA-163685	Integration of energy metabolism
reactome	R-HSA-375165	NCAM signaling for neurite out-growth
reactome	R-HSA-397014	Muscle contraction
reactome	R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
reactome	R-HSA-419037	NCAM1 interactions
reactome	R-HSA-422356	Regulation of insulin secretion
reactome	R-HSA-422356	Regulation of insulin secretion
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-5576891	Cardiac conduction
reactome	R-HSA-5576892	Phase 0 - rapid depolarisation
reactome	R-HSA-5576893	Phase 2 - plateau phase

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD280	CYTOCHALASIN B	5
iGMDRD446	LY 2183240	10
iGMDRD61	Kinetin riboside	2
iGMDRD193	Fqi1	3
iGMDRD639	YK 4-279	3
iGMDRD781	Sirolimus	7
iGMDRD433	Lexibulin	3
iGMDRD151	CHM-1	2
iGMDRD126	Tipifarnib	8
iGMDRD772	BRD4770	2
iGMDRD889	Compound 7d-cis	3
iGMDRD60	Quinoclamine	3
iGMDRD64	Parbendazole	3
iGMDRD690	PRIMA-1MET	2
iGMDRD444	Tivantinib	2
iGMDRD451	Serdemetan	2
iGMDRD524	ISX-9	2
iGMDRD23	Gossypol	2
iGMDRD356	PNU-74654	1
iGMDRD399	Selumetinib	2
iGMDRD730	Kahalalide F	3
iGMDRD74	Idarubicin	3
iGMDRD188	Piperlongumine	6
iGMDRD100	Zebularine	5
iGMDRD780	PP-30	2
iGMDRD506	Fedratinib	5
iGMDRD171	Pemetrexed	2
iGMDRD187	BRD9876	4
iGMDRD870	BRD63610	3
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD138	PX 12	2
iGMDRD255	SB225002	5
iGMDRD802	4-methylfasudil	5
iGMDRD123	Isoevodiamine	5
iGMDRD177	Teniposide	3
iGMDRD901	ELCPK	1
iGMDRD945	ML214	2
iGMDRD85	Ursolic acid	2
iGMDRD341	Triacsin c	3
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD424	Tamatinib	2
iGMDRD532	Olaparib	3
iGMDRD701	NVP-AUY922	1
iGMDRD79	Gemcitabine	2
iGMDRD307	Manumycin A	2
iGMDRD84	Lovastatin acid	2
iGMDRD512	nutlin 3	3
iGMDRD300	Tozasertib	2
iGMDRD505	Pevonedistat	3
iGMDRD353	PD0325901	1
iGMDRD872	BRD7137	5
iGMDRD882	CIL41	2
iGMDRD367	Ro 28-1675	2
iGMDRD286	Nsc 632839	2
iGMDRD871	BRD6368	5
iGMDRD289	Parthenolide	2
iGMDRD481	Dactolisib	2
iGMDRD158	NSC141540	2
iGMDRD202	Curcumin	4
iGMDRD137	Indisulam	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNB2

SITE

DATATYPES

CLASSFICATION

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