LTK


Summary: The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
leukocyte receptor tyrosine kinaseMIM:151520Ensembl:ENSG00000062524HGNC:HGNC:6721PA3048315q15.1

GO terms in LTK


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIEAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
CCIEAGO:0005622intracellular
CCIBAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0016020membrane
CCIBAGO:0043235receptor complex
BPIBAGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPIEAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007275multicellular organism development
BPIDAGO:0008283cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0010666positive regulation of cardiac muscle cell apoptotic process
BPIMPGO:0010976positive regulation of neuron projection development
BPIMPGO:0014065phosphatidylinositol 3-kinase signaling
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0071300cellular response to retinoic acid

Gene expression in normal tissue: LTK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LTK


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD546BMS-7548072
iGMDRD427ABT7372
iGMDRD494Neopeltolide4
iGMDRD126Tipifarnib2
iGMDRD889Compound 7d-cis2
iGMDRD772BRD47702
iGMDRD420Leucascandrolide A2
iGMDRD1008SR-II-138A2
iGMDRD579PF7505
iGMDRD466Chaetocin3
iGMDRD634SCHEMBL26080413
iGMDRD375GW-4058335
iGMDRD446LY 21832402
iGMDRD201SKI II3
iGMDRD193Fqi13
iGMDRD885Compound 1103
iGMDRD52Rotenone2
iGMDRD270Ciclosporin2
iGMDRD8024-methylfasudil5
iGMDRD64Parbendazole4
iGMDRD268Cerulenin2
iGMDRD23Gossypol2
iGMDRD524ISX-92
iGMDRD188Piperlongumine2
iGMDRD100Zebularine2
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate2
iGMDRD888Compound 441
iGMDRD577BIX012945
iGMDRD506Fedratinib7
iGMDRD562Navitoclax4
iGMDRD424Tamatinib1
iGMDRD652UNC06382
iGMDRD79Gemcitabine5
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine2
iGMDRD154NSC237663
iGMDRD314Tanespimycin2
iGMDRD221Tamoxifen3
iGMDRD481Dactolisib3
iGMDRD77Itraconazole5
iGMDRD213SMR0000686501
iGMDRD137Indisulam4
iGMDRD300Tozasertib3
iGMDRD505Pevonedistat2
iGMDRD246NPC262
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16753
iGMDRD872BRD71372
iGMDRD329Merck602
iGMDRD269Purmorphamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LTK

​​​​