MSH3


Summary: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mutS homolog 3MIM:600887Ensembl:ENSG00000113318HGNC:HGNC:7326PA311345q14.1

Gene Categories:

DNA REPAIR

GO terms in MSH3


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005654nucleoplasm
CCHDAGO:0016020membrane
CCIBAGO:0032300mismatch repair complex
CCIBAGO:0032302MutSbeta complex
CCIDAGO:0032302MutSbeta complex
BPIBAGO:0000710meiotic mismatch repair
BPIBAGO:0000735removal of nonhomologous ends
BPIDAGO:0006281DNA repair
BPIBAGO:0006298mismatch repair
BPIMPGO:0006298mismatch repair
BPTASGO:0006298mismatch repair
BPIBAGO:0006312mitotic recombination
BPIBAGO:0007131reciprocal meiotic recombination
BPIBAGO:0016447somatic recombination of immunoglobulin gene segments
BPIBAGO:0043111replication fork arrest
BPIBAGO:0043570maintenance of DNA repeat elements
BPIMPGO:0043570maintenance of DNA repeat elements
BPIDAGO:0045910negative regulation of DNA recombination
BPIBAGO:0051096positive regulation of helicase activity
BPIDAGO:0051096positive regulation of helicase activity
MFIBAGO:0000403Y-form DNA binding
MFIBAGO:0000404heteroduplex DNA loop binding
MFIBAGO:0000406double-strand/single-strand DNA junction binding
MFIBAGO:0003684damaged DNA binding
MFIBAGO:0003697single-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008094DNA-dependent ATPase activity
MFIBAGO:0019237centromeric DNA binding
MFIPIGO:0019899enzyme binding
MFIBAGO:0030983mismatched DNA binding
MFIDAGO:0030983mismatched DNA binding
MFIDAGO:0032137guanine/thymine mispair binding
MFIDAGO:0032139dinucleotide insertion or deletion binding
MFIBAGO:0032142single guanine insertion binding
MFIDAGO:0032142single guanine insertion binding
MFIBAGO:0032181dinucleotide repeat insertion binding
MFIDAGO:0032181dinucleotide repeat insertion binding
MFIBAGO:0032357oxidized purine DNA binding
MFIDAGO:0032357oxidized purine DNA binding
MFIDAGO:0042803protein homodimerization activity

Gene expression in normal tissue: MSH3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSH3


DatabasePathway IDPathway Des.
kegghsa03430Mismatch repair - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
reactomeR-HSA-1643685Disease
reactomeR-HSA-5358508Mismatch Repair
reactomeR-HSA-5358508Mismatch Repair
reactomeR-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
reactomeR-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
reactomeR-HSA-5423599Diseases of Mismatch Repair (MMR)
reactomeR-HSA-5632927Defective Mismatch Repair Associated With MSH3
reactomeR-HSA-5632928Defective Mismatch Repair Associated With MSH2
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73894DNA Repair

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250023
iGMDRD8012,4-dideoxy-DC-45-A25
iGMDRD885Compound 1102
iGMDRD318PAC-14
iGMDRD187BRD98763
iGMDRD100Zebularine1
iGMDRD74Idarubicin1
iGMDRD730Kahalalide F4
iGMDRD399Selumetinib3
iGMDRD577BIX012942
iGMDRD506Fedratinib3
iGMDRD398Sepantronium3
iGMDRD780PP-306
iGMDRD690PRIMA-1MET4
iGMDRD60Quinoclamine2
iGMDRD369TGX-1153
iGMDRD268Cerulenin4
iGMDRD598QS-114
iGMDRD451Serdemetan3
iGMDRD126Tipifarnib5
iGMDRD76Simvastatin2
iGMDRD889Compound 7d-cis2
iGMDRD579PF7505
iGMDRD425ERASTIN5
iGMDRD316N9-Isopropyl-olomoucine5
iGMDRD639YK 4-2791
iGMDRD163all trans Retinoic Acid5
iGMDRD793BEC (hydrochloride)4
iGMDRD61Kinetin riboside5
iGMDRD280CYTOCHALASIN B5
iGMDRD375GW-4058334
iGMDRD137Indisulam2
iGMDRD221Tamoxifen5
iGMDRD6AM-5807
iGMDRD192CIL564
iGMDRD415LE-1354
iGMDRD481Dactolisib3
iGMDRD213SMR0000686505
iGMDRD67PENFLURIDOL3
iGMDRD367Ro 28-16754
iGMDRD892DNA-PKc inhibitor2
iGMDRD329Merck608
iGMDRD300Tozasertib1
iGMDRD147Prima-15
iGMDRD84Lovastatin acid3
iGMDRD307Manumycin A6
iGMDRD248BRD43543
iGMDRD532Olaparib5
iGMDRD424Tamatinib3
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD341Triacsin c4
iGMDRD351GW843682X3
iGMDRD237ABT-7515
iGMDRD123Isoevodiamine1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSH3

​​​​