PREX2


Summary: The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2MIM:612139Ensembl:ENSG00000046889HGNC:HGNC:22950PA1647251038q13.2

Gene Categories:

KINASE

GO terms in PREX2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005096GTPase activator activity
MFIBAGO:0030676Rac guanyl-nucleotide exchange factor activity
MFIDAGO:0030676Rac guanyl-nucleotide exchange factor activity
BPIBAGO:0006469negative regulation of protein kinase activity
BPIBAGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0008344adult locomotory behavior
BPIEAGO:0014065phosphatidylinositol 3-kinase signaling
BPIBAGO:0032007negative regulation of TOR signaling
BPIEAGO:0035023regulation of Rho protein signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPIEAGO:0048813dendrite morphogenesis
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane

Gene expression in normal tissue: PREX2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PREX2


DatabasePathway IDPathway Des.
pidrac1_reg_pathwayRegulation of RAC1 activity
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832406
iGMDRD201SKI II3
iGMDRD639YK 4-2792
iGMDRD152179324-69-72
iGMDRD193Fqi14
iGMDRD394BX-7953
iGMDRD280CYTOCHALASIN B2
iGMDRD466Chaetocin2
iGMDRD433Lexibulin2
iGMDRD151CHM-15
iGMDRD1008SR-II-138A3
iGMDRD670ML 2102
iGMDRD779PRL-3 Inhibitor I2
iGMDRD100Zebularine3
iGMDRD577BIX012943
iGMDRD780PP-302
iGMDRD562Navitoclax5
iGMDRD398Sepantronium3
iGMDRD369TGX-1152
iGMDRD64Parbendazole6
iGMDRD524ISX-96
iGMDRD451Serdemetan2
iGMDRD480KU00606483
iGMDRD138PX 123
iGMDRD255SB2250023
iGMDRD260FQI-25
iGMDRD318PAC-13
iGMDRD869BRD553191
iGMDRD187BRD98763
iGMDRD85Ursolic acid2
iGMDRD536PLX-47201
iGMDRD351GW843682X1
iGMDRD237ABT-7512
iGMDRD211(1S,3R)-RSL33
iGMDRD123Isoevodiamine1
iGMDRD154NSC237662
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD511CHEMBL3993793
iGMDRD435BI-25365
iGMDRD945ML2143
iGMDRD84Lovastatin acid3
iGMDRD512nutlin 34
iGMDRD79Gemcitabine4
iGMDRD286Nsc 6328396
iGMDRD882CIL413
iGMDRD505Pevonedistat2
iGMDRD552AZD-17753
iGMDRD246NPC263
iGMDRD353PD03259011
iGMDRD202Curcumin1
iGMDRD158NSC1415403
iGMDRD105Triptolide1
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369243
iGMDRD77Itraconazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PREX2

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