TNK2


Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tyrosine kinase non receptor 2MIM:606994Ensembl:ENSG00000061938HGNC:HGNC:19297PA1349097593q29

GO terms in TNK2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006897endocytosis
BPTASGO:0007166cell surface receptor signaling pathway
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPTASGO:0007264small GTPase mediated signal transduction
BPIDAGO:0016310phosphorylation
BPIBAGO:0030154cell differentiation
BPIEAGO:0034260negative regulation of GTPase activity
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042127regulation of cell proliferation
BPIBAGO:0045087innate immune response
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:2000369regulation of clathrin-dependent endocytosis
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCISSGO:0005768endosome
CCIDAGO:0005886plasma membrane
CCIDAGO:0005905clathrin-coated pit
CCIEAGO:0005912adherens junction
CCHDAGO:0016020membrane
CCIDAGO:0030136clathrin-coated vesicle
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIEAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0070436Grb2-EGFR complex
MFIEAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFTASGO:0005095GTPase inhibitor activity
MFIBAGO:0005102signaling receptor binding
MFIDAGO:0005154epidermal growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
MFISSGO:0050699WW domain binding

Gene expression in normal tissue: TNK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNK2


DatabasePathway IDPathway Des.
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP524G13 Signaling Pathway
pidcdc42_pathwayCDC42 signaling events
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD405PIK-752
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD512nutlin 32
iGMDRD123Isoevodiamine2
iGMDRD237ABT-7515
iGMDRD314Tanespimycin2
iGMDRD57Chloropentafluorobenzene3
iGMDRD351GW843682X4
iGMDRD415LE-1352
iGMDRD289Parthenolide2
iGMDRD6AM-5801
iGMDRD105Triptolide2
iGMDRD5Tyrphostin AG 14782
iGMDRD137Indisulam12
iGMDRD202Curcumin4
iGMDRD103SN-385
iGMDRD82Quiflapon1
iGMDRD246NPC262
iGMDRD505Pevonedistat3
iGMDRD483SCH-5290741
iGMDRD494Neopeltolide2
iGMDRD1008SR-II-138A3
iGMDRD772BRD47702
iGMDRD425ERASTIN2
iGMDRD634SCHEMBL26080412
iGMDRD375GW-4058331
iGMDRD679Bistramide A2
iGMDRD394BX-7951
iGMDRD280CYTOCHALASIN B1
iGMDRD466Chaetocin3
iGMDRD2PK-111952
iGMDRD152179324-69-72
iGMDRD193Fqi14
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD446LY 21832401
iGMDRD294Batimastat2
iGMDRD870BRD636102
iGMDRD171Pemetrexed6
iGMDRD8024-methylfasudil2
iGMDRD474Avrainvillamide2
iGMDRD513BML-2592
iGMDRD524ISX-95
iGMDRD356PNU-746542
iGMDRD60Quinoclamine3
iGMDRD64Parbendazole4
iGMDRD562Navitoclax2
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib3
iGMDRD74Idarubicin5
iGMDRD188Piperlongumine5
iGMDRD100Zebularine4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNK2

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