TRIO
Summary: This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| trio Rho guanine nucleotide exchange factor | MIM:601893 | Ensembl:ENSG00000038382 | HGNC:HGNC:12303 | PA36982 | 5p15.2 |
GO terms in TRIO
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
Gene expression in normal tissue: TRIO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIO
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | rhopathway | rho cell motility signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD499 | PDMP | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD560 | MK-2206 | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD130 | Enzastaurin | 1 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD54 | Phenformin | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD1019 | TL-2-105 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIO
CLASSFICATION
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