EPHA4


Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor A4MIM:602188Ensembl:ENSG00000116106HGNC:HGNC:3388PA278202q36.1

GO terms in EPHA4


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFISSGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFISSGO:0005005transmembrane-ephrin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIGIGO:0016301kinase activity
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0042731PH domain binding
MFIEAGO:0042802identical protein binding
MFIEAGO:0046875ephrin receptor binding
MFIDAGO:0097161DH domain binding
MFIPIGO:1990782protein tyrosine kinase binding
BPIEAGO:0007155cell adhesion
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007628adult walking behavior
BPISSGO:0008045motor neuron axon guidance
BPIEAGO:0008347glial cell migration
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0010977negative regulation of neuron projection development
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0021957corticospinal tract morphogenesis
BPIBAGO:0030154cell differentiation
BPIBAGO:0030517negative regulation of axon extension
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPISSGO:0043087regulation of GTPase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0043507positive regulation of JUN kinase activity
BPIDAGO:0046777protein autophosphorylation
BPIGIGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPISSGO:0048681negative regulation of axon regeneration
BPISSGO:0048710regulation of astrocyte differentiation
BPISSGO:0050770regulation of axonogenesis
BPIEAGO:0050775positive regulation of dendrite morphogenesis
BPIGIGO:0050821protein stabilization
BPISSGO:0061001regulation of dendritic spine morphogenesis
BPISSGO:0061098positive regulation of protein tyrosine kinase activity
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0072178nephric duct morphogenesis
BPISSGO:0097155fasciculation of sensory neuron axon
BPISSGO:0097156fasciculation of motor neuron axon
BPISSGO:0097485neuron projection guidance
BPISSGO:0106030neuron projection fasciculation
BPISSGO:1900272negative regulation of long-term synaptic potentiation
BPIGIGO:1902004positive regulation of amyloid-beta formation
BPIGIGO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
BPIGIGO:1903051negative regulation of proteolysis involved in cellular protein catabolic process
BPISSGO:1904646cellular response to amyloid-beta
BPISSGO:1905244regulation of modification of synaptic structure
BPIDAGO:2001108positive regulation of Rho guanyl-nucleotide exchange factor activity
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIEAGO:0005741mitochondrial outer membrane
CCIEAGO:0005783endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCNASGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCIEAGO:0009986cell surface
CCIEAGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCIEAGO:0030175filopodium
CCISSGO:0030424axon
CCISSGO:0030425dendrite
CCIEAGO:0031594neuromuscular junction
CCISSGO:0031901early endosome membrane
CCIBAGO:0043005neuron projection
CCIBAGO:0043197dendritic spine
CCISSGO:0043197dendritic spine
CCISSGO:0043198dendritic shaft
CCIEAGO:0043204perikaryon
CCIBAGO:0043235receptor complex
CCIEAGO:0043679axon terminus
CCIEAGO:0044295axonal growth cone
CCIEAGO:0045211postsynaptic membrane

Gene expression in normal tissue: EPHA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA4


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2854Gene regulatory network modelling somitogenesis
pidepha_fwdpathwayEPHA forward signaling
kegghsa04360Axon guidance - Homo sapiens (human)
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck602
iGMDRD662JQ-13
iGMDRD300Tozasertib3
iGMDRD246NPC262
iGMDRD147Prima-12
iGMDRD103SN-382
iGMDRD158NSC1415406
iGMDRD202Curcumin2
iGMDRD137Indisulam2
iGMDRD415LE-1353
iGMDRD267Oligomycin A2
iGMDRD213SMR0000686503
iGMDRD289Parthenolide3
iGMDRD351GW843682X3
iGMDRD57Chloropentafluorobenzene2
iGMDRD945ML2142
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine3
iGMDRD248BRD43543
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A3
iGMDRD330BRD41323
iGMDRD523Cyanoquinoline, 113
iGMDRD79Gemcitabine6
iGMDRD532Olaparib3
iGMDRD780PP-303
iGMDRD398Sepantronium2
iGMDRD598QS-113
iGMDRD268Cerulenin3
iGMDRD451Serdemetan2
iGMDRD690PRIMA-1MET3
iGMDRD64Parbendazole3
iGMDRD255SB2250023
iGMDRD260FQI-22
iGMDRD138PX 125
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD52Rotenone4
iGMDRD193Fqi13
iGMDRD793BEC (hydrochloride)2
iGMDRD163all trans Retinoic Acid3
iGMDRD152179324-69-72
iGMDRD201SKI II3
iGMDRD280CYTOCHALASIN B3
iGMDRD387CHIR-990212
iGMDRD599Salermide2
iGMDRD889Compound 7d-cis1
iGMDRD1008SR-II-138A3
iGMDRD772BRD47703
iGMDRD425ERASTIN1
iGMDRD126Tipifarnib3
iGMDRD151CHM-13
iGMDRD494Neopeltolide1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA4

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