EPHA4
Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor A4 | MIM:602188 | Ensembl:ENSG00000116106 | HGNC:HGNC:3388 | PA27820 | 2q36.1 |
GO terms in EPHA4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | ISS | GO:0005004 | GPI-linked ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | ISS | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IGI | GO:0016301 | kinase activity |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0042731 | PH domain binding |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046875 | ephrin receptor binding |
| MF | IDA | GO:0097161 | DH domain binding |
| MF | IPI | GO:1990782 | protein tyrosine kinase binding |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007628 | adult walking behavior |
| BP | ISS | GO:0008045 | motor neuron axon guidance |
| BP | IEA | GO:0008347 | glial cell migration |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | ISS | GO:0010977 | negative regulation of neuron projection development |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0021957 | corticospinal tract morphogenesis |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030517 | negative regulation of axon extension |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043087 | regulation of GTPase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IGI | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | ISS | GO:0048681 | negative regulation of axon regeneration |
| BP | ISS | GO:0048710 | regulation of astrocyte differentiation |
| BP | ISS | GO:0050770 | regulation of axonogenesis |
| BP | IEA | GO:0050775 | positive regulation of dendrite morphogenesis |
| BP | IGI | GO:0050821 | protein stabilization |
| BP | ISS | GO:0061001 | regulation of dendritic spine morphogenesis |
| BP | ISS | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0072178 | nephric duct morphogenesis |
| BP | ISS | GO:0097155 | fasciculation of sensory neuron axon |
| BP | ISS | GO:0097156 | fasciculation of motor neuron axon |
| BP | ISS | GO:0097485 | neuron projection guidance |
| BP | ISS | GO:0106030 | neuron projection fasciculation |
| BP | ISS | GO:1900272 | negative regulation of long-term synaptic potentiation |
| BP | IGI | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | IGI | GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| BP | IGI | GO:1903051 | negative regulation of proteolysis involved in cellular protein catabolic process |
| BP | ISS | GO:1904646 | cellular response to amyloid-beta |
| BP | ISS | GO:1905244 | regulation of modification of synaptic structure |
| BP | IDA | GO:2001108 | positive regulation of Rho guanyl-nucleotide exchange factor activity |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030175 | filopodium |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | ISS | GO:0031901 | early endosome membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043197 | dendritic spine |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | ISS | GO:0043198 | dendritic shaft |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IEA | GO:0043679 | axon terminus |
| CC | IEA | GO:0044295 | axonal growth cone |
| CC | IEA | GO:0045211 | postsynaptic membrane |
Gene expression in normal tissue: EPHA4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHA4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2854 | Gene regulatory network modelling somitogenesis |
| pid | epha_fwdpathway | EPHA forward signaling |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD79 | Gemcitabine | 6 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD793 | BEC (hydrochloride) | 2 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHA4
CLASSFICATION
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