EPHA7


Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor A7MIM:602190Ensembl:ENSG00000135333HGNC:HGNC:3390PA278226q16.1

GO terms in EPHA7


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFISSGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFISSGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFISSGO:0008046axon guidance receptor activity
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFISSGO:0045499chemorepellent activity
MFIEAGO:0046875ephrin receptor binding
BPIEAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0006915apoptotic process
BPIBAGO:0007275multicellular organism development
BPISSGO:0007420brain development
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0016310phosphorylation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0022407regulation of cell-cell adhesion
BPIBAGO:0030154cell differentiation
BPIEAGO:0031290retinal ganglion cell axon guidance
BPISSGO:0031952regulation of protein autophosphorylation
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPISSGO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0043525positive regulation of neuron apoptotic process
BPIDAGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPIEAGO:0048671negative regulation of collateral sprouting
BPISSGO:0048755branching morphogenesis of a nerve
BPIDAGO:0050730regulation of peptidyl-tyrosine phosphorylation
BPISSGO:0050919negative chemotaxis
BPIEAGO:0051964negative regulation of synapse assembly
BPIDAGO:0070372regulation of ERK1 and ERK2 cascade
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0072178nephric duct morphogenesis
CCIBAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIEAGO:0030425dendrite
CCIEAGO:0031594neuromuscular junction
CCIBAGO:0043005neuron projection
CCIEAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCIEAGO:0045211postsynaptic membrane

Gene expression in normal tissue: EPHA7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA7


DatabasePathway IDPathway Des.
pidepha_fwdpathwayEPHA forward signaling
kegghsa04360Axon guidance - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD599Salermide1
iGMDRD76Simvastatin3
iGMDRD126Tipifarnib4
iGMDRD433Lexibulin1
iGMDRD781Sirolimus2
iGMDRD670ML 2102
iGMDRD144NSC953976
iGMDRD427ABT7373
iGMDRD61Kinetin riboside7
iGMDRD152179324-69-76
iGMDRD446LY 21832402
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A1
iGMDRD474Avrainvillamide4
iGMDRD138PX 125
iGMDRD318PAC-15
iGMDRD52Rotenone4
iGMDRD187BRD98761
iGMDRD870BRD636104
iGMDRD782DC-45-A22
iGMDRD506Fedratinib2
iGMDRD562Navitoclax5
iGMDRD188Piperlongumine2
iGMDRD100Zebularine2
iGMDRD74Idarubicin3
iGMDRD451Serdemetan2
iGMDRD60Quinoclamine2
iGMDRD84Lovastatin acid3
iGMDRD486Tosedostat3
iGMDRD330BRD41322
iGMDRD79Gemcitabine5
iGMDRD560MK-22062
iGMDRD116CD4371
iGMDRD57Chloropentafluorobenzene3
iGMDRD698Neratinib4
iGMDRD85Ursolic acid4
iGMDRD945ML2143
iGMDRD211(1S,3R)-RSL33
iGMDRD177Teniposide2
iGMDRD5Tyrphostin AG 14784
iGMDRD103SN-382
iGMDRD137Indisulam4
iGMDRD251ML1624
iGMDRD121GMX17787
iGMDRD202Curcumin3
iGMDRD158NSC1415402
iGMDRD289Parthenolide5
iGMDRD329Merck603
iGMDRD366PI-1032
iGMDRD871BRD63683
iGMDRD414MST-3122
iGMDRD872BRD71373
iGMDRD42Vorinostat3
iGMDRD322FK 8661
iGMDRD505Pevonedistat3
iGMDRD263AACOCF35
iGMDRD552AZD-17755

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA7

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