FLT3


Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fms related tyrosine kinase 3MIM:136351Ensembl:ENSG00000122025HGNC:HGNC:3765PA2818113q12.2

GO terms in FLT3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFTASGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFISSGO:0004896cytokine receptor activity
MFTASGO:0005021vascular endothelial growth factor-activated receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0019838growth factor binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIEAGO:0035259glucocorticoid receptor binding
MFTASGO:0042803protein homodimerization activity
MFIMPGO:0043621protein self-association
MFIEAGO:0044877protein-containing complex binding
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005788endoplasmic reticulum lumen
CCIEAGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0032991protein-containing complex
CCIBAGO:0043235receptor complex
BPISSGO:0001776leukocyte homeostasis
BPISSGO:0002318myeloid progenitor cell differentiation
BPISSGO:0002328pro-B cell differentiation
BPTASGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007275multicellular organism development
BPTASGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIEAGO:0010243response to organonitrogen compound
BPTASGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPTASGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIDAGO:0030097hemopoiesis
BPIBAGO:0030154cell differentiation
BPISSGO:0030183B cell differentiation
BPIEAGO:0031100animal organ regeneration
BPIBAGO:0033674positive regulation of kinase activity
BPISSGO:0035726common myeloid progenitor cell proliferation
BPIEAGO:0038084vascular endothelial growth factor signaling pathway
BPTASGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPTASGO:0042981regulation of apoptotic process
BPIBAGO:0043066negative regulation of apoptotic process
BPTASGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPTASGO:0043410positive regulation of MAPK cascade
BPTASGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPISSGO:0046651lymphocyte proliferation
BPTASGO:0046777protein autophosphorylation
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0071345cellular response to cytokine stimulus
BPTASGO:0071345cellular response to cytokine stimulus
BPIEAGO:0071385cellular response to glucocorticoid stimulus
BPISSGO:0097028dendritic cell differentiation

Gene expression in normal tissue: FLT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLT3


DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449836Other interleukin signaling
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
pharmgkbPA165959425Pathway_PA165959425
pharmgkbPA165959584Sorafenib Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD332A-7700411
iGMDRD60Quinoclamine2
iGMDRD677ABT-199 (GDC-0199)1
iGMDRD138PX 121
iGMDRD491TAE-6841
iGMDRD913FLT3 inhibitor2
iGMDRD413Crenolanib2
iGMDRD134Sorafenib22
iGMDRD318PAC-12
iGMDRD440Nutlin-3A1
iGMDRD885Compound 1102
iGMDRD388YM2016361
iGMDRD446LY 21832401
iGMDRD498GW441756X1
iGMDRD163all trans Retinoic Acid1
iGMDRD297Austocystin D2
iGMDRD378ZM-4474392
iGMDRD1008SR-II-138A2
iGMDRD144NSC953972
iGMDRD354Midostaurin6
iGMDRD3PD-1730741
iGMDRD269Purmorphamine3
iGMDRD472PF-5622711
iGMDRD505Pevonedistat2
iGMDRD556Quizartinib24
iGMDRD56Azacitidine2
iGMDRD515Staurosporine2
iGMDRD434BMS-5369242
iGMDRD241Sunitinib5
iGMDRD481Dactolisib1
iGMDRD267Oligomycin A1
iGMDRD551Ponatinib6
iGMDRD177Teniposide3
iGMDRD382CEP-7012
iGMDRD307Manumycin A2
iGMDRD125BIRB-7961
iGMDRD116CD4372
iGMDRD424Tamatinib2
iGMDRD188Piperlongumine2
iGMDRD4AG-12961
iGMDRD399Selumetinib4
iGMDRD23Gossypol3
iGMDRD568SCHEMBL150055121
iGMDRD493GSK269962A1
iGMDRD294Batimastat3
iGMDRD394BX-7951
iGMDRD694HG6-64-11
iGMDRD126Tipifarnib1
iGMDRD1034WZ31051
iGMDRD433Lexibulin3
iGMDRD571Cabozantinib2
iGMDRD443Linifanib1
iGMDRD654SL 0101-11
iGMDRD476WH-4-0231
iGMDRD329Merck605
iGMDRD421AZD77622
iGMDRD158NSC1415402
iGMDRD202Curcumin6
iGMDRD705Nakiterpiosin2
iGMDRD77Itraconazole2
iGMDRD65Daunorubicin2
iGMDRD564GSK-6503941
iGMDRD961novel FLT3 inhibitor2
iGMDRD315SU-56142
iGMDRD162All-trans Retinoic Acid2
iGMDRD111Lestaurtinib2
iGMDRD523Cyanoquinoline, 113

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLT3

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