AXIN1
Summary: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| axin 1 | MIM:603816 | Ensembl:ENSG00000103126 | HGNC:HGNC:903 | PA25195 | 16p13.3 |
GO terms in AXIN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | NAS | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0030111 | regulation of Wnt signaling pathway |
| BP | IDA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | NAS | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IDA | GO:0032147 | activation of protein kinase activity |
| BP | NAS | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway |
| BP | IDA | GO:0034622 | cellular protein-containing complex assembly |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IC | GO:0045732 | positive regulation of protein catabolic process |
| BP | IDA | GO:0045732 | positive regulation of protein catabolic process |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0046330 | positive regulation of JNK cascade |
| BP | IMP | GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| BP | IC | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:1904885 | beta-catenin destruction complex assembly |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
| BP | ISS | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016328 | lateral plasma membrane |
| CC | IDA | GO:0030877 | beta-catenin destruction complex |
| CC | ISS | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0071944 | cell periphery |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | ISS | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0030159 | receptor signaling complex scaffold activity |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IMP | GO:0032947 | protein-containing complex scaffold activity |
| MF | TAS | GO:0035591 | signaling adaptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | ISS | GO:0042802 | identical protein binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0046332 | SMAD binding |
| MF | ISS | GO:0070016 | armadillo repeat domain binding |
| MF | IPI | GO:0070411 | I-SMAD binding |
Gene expression in normal tissue: AXIN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AXIN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | myc_pathway | C-MYC pathway |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| netpath | Pathway_Wnt | Wnt |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2773 | Degradation of beta-catenin by the destruction complex |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP2870 | Extracellular vesicle-mediated signaling in recipient cells |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3664 | Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196299 | Beta-catenin phosphorylation cascade |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4641257 | Degradation of AXIN |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-4839735 | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| reactome | R-HSA-4839743 | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| reactome | R-HSA-4839744 | truncated APC mutants destabilize the destruction complex |
| reactome | R-HSA-4839748 | AMER1 mutants destabilize the destruction complex |
| reactome | R-HSA-5339716 | Misspliced GSK3beta mutants stabilize beta-catenin |
| reactome | R-HSA-5358747 | S33 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358749 | S37 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358751 | S45 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358752 | T41 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5467337 | APC truncation mutants have impaired AXIN binding |
| reactome | R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex |
| reactome | R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD522 | ML-030 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 8 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AXIN1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.