PTPRD
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type D | MIM:601598 | Ensembl:ENSG00000153707 | HGNC:HGNC:9668 | PA34013 | 9p24.1-p23 |
GO terms in PTPRD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| MF | ISS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0050839 | cell adhesion molecule binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | NAS | GO:0006796 | phosphate-containing compound metabolic process |
| BP | ISS | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | TAS | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway |
| BP | ISS | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | ISS | GO:0050775 | positive regulation of dendrite morphogenesis |
| BP | ISS | GO:0051965 | positive regulation of synapse assembly |
| BP | ISS | GO:0097105 | presynaptic membrane assembly |
Gene expression in normal tissue: PTPRD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-388844 | Receptor-type tyrosine-protein phosphatases |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-8849932 | Synaptic adhesion-like molecules |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD420 | Leucascandrolide A | 12 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD67 | PENFLURIDOL | 1 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD925 | IGF1R inhibitor | 1 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD266 | Cucurbitacin I | 1 |
| iGMDRD995 | R1507 | 1 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD451 | Serdemetan | 7 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD924 | IGF1R antibodies | 1 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD884 | Cixutumumab | 1 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD267 | Oligomycin A | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRD
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