ARFGEF1


Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADP ribosylation factor guanine nucleotide exchange factor 1MIM:604141Ensembl:ENSG00000066777HGNC:HGNC:15772PA1349081978q13.2

GO terms in ARFGEF1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005085guanyl-nucleotide exchange factor activity
MFIBAGO:0005086ARF guanyl-nucleotide exchange factor activity
MFIDAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIPIGO:0017022myosin binding
MFIDAGO:0034237protein kinase A regulatory subunit binding
CCIDAGO:0000139Golgi membrane
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005802trans-Golgi network
CCISSGO:0005802trans-Golgi network
CCIDAGO:0005829cytosol
CCIEAGO:0016363nuclear matrix
CCIDAGO:0030532small nuclear ribonucleoprotein complex
CCIDAGO:0048471perinuclear region of cytoplasm
BPTASGO:0006887exocytosis
BPIMPGO:0007030Golgi organization
BPIMPGO:0010256endomembrane system organization
BPIEAGO:0015031protein transport
BPIBAGO:0016192vesicle-mediated transport
BPIMPGO:0030837negative regulation of actin filament polymerization
BPIEAGO:0031175neuron projection development
BPIEAGO:0032012regulation of ARF protein signal transduction
BPIDAGO:0034260negative regulation of GTPase activity
BPIEAGO:0051897positive regulation of protein kinase B signaling
BPIMPGO:0090284positive regulation of protein glycosylation in Golgi
BPIMPGO:0090303positive regulation of wound healing
BPIMPGO:2000114regulation of establishment of cell polarity

Gene expression in normal tissue: ARFGEF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARFGEF1


DatabasePathway IDPathway Des.
kegghsa04144Endocytosis - Homo sapiens (human)
biocartaarappathwayadp-ribosylation factor
biocartapar1pathwaythrombin signaling and protease-activated receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD679Bistramide A6
iGMDRD394BX-7951
iGMDRD639YK 4-2792
iGMDRD193Fqi11
iGMDRD446LY 21832404
iGMDRD494Neopeltolide4
iGMDRD779PRL-3 Inhibitor I3
iGMDRD670ML 2105
iGMDRD144NSC953976
iGMDRD889Compound 7d-cis4
iGMDRD420Leucascandrolide A3
iGMDRD126Tipifarnib1
iGMDRD151CHM-14
iGMDRD268Cerulenin3
iGMDRD451Serdemetan1
iGMDRD444Tivantinib2
iGMDRD64Parbendazole3
iGMDRD888Compound 442
iGMDRD577BIX012942
iGMDRD780PP-307
iGMDRD398Sepantronium2
iGMDRD188Piperlongumine2
iGMDRD318PAC-11
iGMDRD207Capsaicin3
iGMDRD782DC-45-A22
iGMDRD8024-methylfasudil3
iGMDRD260FQI-22
iGMDRD270Ciclosporin3
iGMDRD138PX 125
iGMDRD511CHEMBL3993792
iGMDRD945ML2142
iGMDRD901ELCPK1
iGMDRD211(1S,3R)-RSL34
iGMDRD351GW843682X5
iGMDRD698Neratinib5
iGMDRD219Bax channel blocker3
iGMDRD341Triacsin c2
iGMDRD523Cyanoquinoline, 112
iGMDRD405PIK-753
iGMDRD116CD4376
iGMDRD424Tamatinib3
iGMDRD584VER 1550082
iGMDRD148Pifithrin-mu3
iGMDRD322FK 8662
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib2
iGMDRD147Prima-12
iGMDRD263AACOCF31
iGMDRD552AZD-17752
iGMDRD329Merck604
iGMDRD658CHEMBL16730391
iGMDRD882CIL412
iGMDRD77Itraconazole3
iGMDRD231Importazole2
iGMDRD105Triptolide1
iGMDRD705Nakiterpiosin2
iGMDRD289Parthenolide2
iGMDRD6AM-5803
iGMDRD103SN-386
iGMDRD202Curcumin1
iGMDRD251ML1623
iGMDRD137Indisulam2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARFGEF1

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