ARFGEF1
Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADP ribosylation factor guanine nucleotide exchange factor 1 | MIM:604141 | Ensembl:ENSG00000066777 | HGNC:HGNC:15772 | PA134908197 | 8q13.2 |
GO terms in ARFGEF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005086 | ARF guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017022 | myosin binding |
| MF | IDA | GO:0034237 | protein kinase A regulatory subunit binding |
| CC | IDA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | ISS | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0030532 | small nuclear ribonucleoprotein complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | TAS | GO:0006887 | exocytosis |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IMP | GO:0010256 | endomembrane system organization |
| BP | IEA | GO:0015031 | protein transport |
| BP | IBA | GO:0016192 | vesicle-mediated transport |
| BP | IMP | GO:0030837 | negative regulation of actin filament polymerization |
| BP | IEA | GO:0031175 | neuron projection development |
| BP | IEA | GO:0032012 | regulation of ARF protein signal transduction |
| BP | IDA | GO:0034260 | negative regulation of GTPase activity |
| BP | IEA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IMP | GO:0090284 | positive regulation of protein glycosylation in Golgi |
| BP | IMP | GO:0090303 | positive regulation of wound healing |
| BP | IMP | GO:2000114 | regulation of establishment of cell polarity |
Gene expression in normal tissue: ARFGEF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARFGEF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| biocarta | arappathway | adp-ribosylation factor |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD780 | PP-30 | 7 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD207 | Capsaicin | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 4 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARFGEF1
CLASSFICATION
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