ARHGEF7
Summary: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho guanine nucleotide exchange factor 7 | MIM:605477 | Ensembl:ENSG00000102606 | HGNC:HGNC:15607 | PA24977 | 13q34 |
GO terms in ARHGEF7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| CC | IEA | GO:0000322 | storage vacuole |
| CC | IEA | GO:0001726 | ruffle |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0005938 | cell cortex |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043025 | neuronal cell body |
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007399 | nervous system development |
| BP | HDA | GO:0010763 | positive regulation of fibroblast migration |
| BP | ISS | GO:0030032 | lamellipodium assembly |
| BP | IEA | GO:0032092 | positive regulation of protein binding |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | HMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | HDA | GO:0048041 | focal adhesion assembly |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0060124 | positive regulation of growth hormone secretion |
| BP | HMP | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IMP | GO:1904424 | regulation of GTP binding |
| BP | HMP | GO:2000394 | positive regulation of lamellipodium morphogenesis |
Gene expression in normal tissue: ARHGEF7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGEF7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | aurora_a_pathway | Aurora A signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD398 | Sepantronium | 8 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD640 | CAY10618 | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD229 | B02 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD67 | PENFLURIDOL | 5 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 9 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD486 | Tosedostat | 4 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD424 | Tamatinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGEF7
CLASSFICATION
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