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CLTCL1

Summary: This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
clathrin heavy chain like 1	MIM:601273	Ensembl:ENSG00000070371	HGNC:HGNC:2093	PA26619	22q11.21

GO terms in CLTCL1

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005769	early endosome
CC	IBA	GO:0005770	late endosome
CC	IDA	GO:0005770	late endosome
CC	IBA	GO:0005802	trans-Golgi network
CC	IDA	GO:0005802	trans-Golgi network
CC	IBA	GO:0005819	spindle
CC	IDA	GO:0005819	spindle
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	IBA	GO:0005905	clathrin-coated pit
CC	IDA	GO:0005905	clathrin-coated pit
CC	HDA	GO:0016020	membrane
CC	IEA	GO:0030130	clathrin coat of trans-Golgi network vesicle
CC	IDA	GO:0030135	coated vesicle
CC	IDA	GO:0030136	clathrin-coated vesicle
CC	IBA	GO:0045334	clathrin-coated endocytic vesicle
CC	NAS	GO:0045334	clathrin-coated endocytic vesicle
CC	IDA	GO:0055037	recycling endosome
CC	HDA	GO:0070062	extracellular exosome
CC	IBA	GO:0071439	clathrin complex
CC	IEA	GO:0071439	clathrin complex
CC	IDA	GO:0097443	sorting endosome
BP	IDA	GO:0000278	mitotic cell cycle
BP	IDA	GO:0000278	mitotic cell cycle
BP	IEA	GO:0006886	intracellular protein transport
BP	IBA	GO:0006898	receptor-mediated endocytosis
BP	IDA	GO:0006898	receptor-mediated endocytosis
BP	TAS	GO:0009653	anatomical structure morphogenesis
BP	IBA	GO:0042147	retrograde transport, endosome to Golgi
BP	IMP	GO:0042147	retrograde transport, endosome to Golgi
BP	IMP	GO:0046326	positive regulation of glucose import
BP	IEA	GO:0048268	clathrin coat assembly
BP	TAS	GO:0061024	membrane organization
MF	IEA	GO:0005198	structural molecule activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0032051	clathrin light chain binding
MF	IEA	GO:0032051	clathrin light chain binding
MF	IBA	GO:0042802	identical protein binding

Gene expression in normal tissue: CLTCL1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLTCL1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-157858	Gap junction trafficking and regulation
reactome	R-HSA-190828	Gap junction trafficking
reactome	R-HSA-190873	Gap junction degradation
reactome	R-HSA-196025	Formation of annular gap junctions
reactome	R-HSA-199991	Membrane Trafficking
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-5653656	Vesicle-mediated transport
reactome	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
reactome	R-HSA-8856828	Clathrin-mediated endocytosis
wikipathways	WP2267	Synaptic Vesicle Pathway
kegg	hsa04142	Lysosome - Homo sapiens (human)
kegg	hsa04144	Endocytosis - Homo sapiens (human)
kegg	hsa04721	Synaptic vesicle cycle - Homo sapiens (human)
kegg	hsa04961	Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegg	hsa05016	Huntington,s disease - Homo sapiens (human)
kegg	hsa05100	Bacterial invasion of epithelial cells - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD237	ABT-751	3
iGMDRD901	ELCPK	3
iGMDRD123	Isoevodiamine	4
iGMDRD154	NSC23766	7
iGMDRD435	BI-2536	3
iGMDRD84	Lovastatin acid	2
iGMDRD307	Manumycin A	3
iGMDRD424	Tamatinib	3
iGMDRD79	Gemcitabine	1
iGMDRD286	Nsc 632839	5
iGMDRD872	BRD7137	5
iGMDRD269	Purmorphamine	2
iGMDRD505	Pevonedistat	3
iGMDRD147	Prima-1	3
iGMDRD552	AZD-1775	2
iGMDRD322	FK 866	2
iGMDRD137	Indisulam	3
iGMDRD121	GMX1778	2
iGMDRD705	Nakiterpiosin	2
iGMDRD6	AM-580	6
iGMDRD481	Dactolisib	2
iGMDRD415	LE-135	2
iGMDRD213	SMR000068650	1
iGMDRD446	LY 2183240	5
iGMDRD797	ISOX DUAL	2
iGMDRD201	SKI II	3
iGMDRD639	YK 4-279	3
iGMDRD193	Fqi1	4
iGMDRD466	Chaetocin	5
iGMDRD634	SCHEMBL2608041	3
iGMDRD126	Tipifarnib	3
iGMDRD433	Lexibulin	6
iGMDRD229	B02	1
iGMDRD889	Compound 7d-cis	3
iGMDRD1008	SR-II-138A	5
iGMDRD579	PF750	5
iGMDRD772	BRD4770	2
iGMDRD779	PRL-3 Inhibitor I	1
iGMDRD427	ABT737	3
iGMDRD188	Piperlongumine	9
iGMDRD100	Zebularine	3
iGMDRD887	Compound 23 citrate	2
iGMDRD399	Selumetinib	1
iGMDRD74	Idarubicin	3
iGMDRD506	Fedratinib	7
iGMDRD224	Necrostatin-1	3
iGMDRD577	BIX01294	6
iGMDRD562	Navitoclax	3
iGMDRD690	PRIMA-1MET	3
iGMDRD64	Parbendazole	8
iGMDRD60	Quinoclamine	9
iGMDRD268	Cerulenin	3
iGMDRD23	Gossypol	3
iGMDRD356	PNU-74654	2
iGMDRD451	Serdemetan	2
iGMDRD444	Tivantinib	2
iGMDRD524	ISX-9	3
iGMDRD138	PX 12	2
iGMDRD255	SB225002	1
iGMDRD802	4-methylfasudil	6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLTCL1

SITE

DATATYPES

CLASSFICATION

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