PEAK1


Summary: This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pseudopodium enriched atypical kinase 1MIM:614248Ensembl:ENSG00000173517HGNC:HGNC:29431PA16612372215q24.3

GO terms in PEAK1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006468protein phosphorylation
BPIDAGO:0016477cell migration
BPIMPGO:0016477cell migration
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIDAGO:0034446substrate adhesion-dependent cell spreading
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0048041focal adhesion assembly
BPIDAGO:0051893regulation of focal adhesion assembly
CCIEAGO:0005737cytoplasm
CCIBAGO:0005925focal adhesion
CCIDAGO:0005925focal adhesion
CCIBAGO:0015629actin cytoskeleton
CCIDAGO:0015629actin cytoskeleton
MFIBAGO:0004672protein kinase activity
MFIDAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIDAGO:0042802identical protein binding

Gene expression in normal tissue: PEAK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PEAK1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD424Tamatinib1
iGMDRD150RITA16
iGMDRD584VER 1550082
iGMDRD512nutlin 33
iGMDRD307Manumycin A2
iGMDRD154NSC237663
iGMDRD123Isoevodiamine7
iGMDRD901ELCPK2
iGMDRD237ABT-7515
iGMDRD351GW843682X3
iGMDRD85Ursolic acid1
iGMDRD341Triacsin c3
iGMDRD267Oligomycin A2
iGMDRD77Itraconazole2
iGMDRD481Dactolisib2
iGMDRD6AM-5802
iGMDRD705Nakiterpiosin3
iGMDRD158NSC1415405
iGMDRD137Indisulam7
iGMDRD322FK 8662
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib1
iGMDRD269Purmorphamine2
iGMDRD329Merck605
iGMDRD414MST-3122
iGMDRD67PENFLURIDOL3
iGMDRD286Nsc 6328395
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide2
iGMDRD144NSC953973
iGMDRD579PF7502
iGMDRD772BRD47702
iGMDRD1008SR-II-138A2
iGMDRD420Leucascandrolide A3
iGMDRD889Compound 7d-cis3
iGMDRD151CHM-16
iGMDRD126Tipifarnib2
iGMDRD634SCHEMBL26080418
iGMDRD280CYTOCHALASIN B1
iGMDRD466Chaetocin2
iGMDRD297Austocystin D2
iGMDRD193Fqi11
iGMDRD446LY 21832404
iGMDRD52Rotenone1
iGMDRD870BRD636105
iGMDRD441TW 372
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD318PAC-16
iGMDRD782DC-45-A23
iGMDRD255SB2250023
iGMDRD270Ciclosporin2
iGMDRD268Cerulenin2
iGMDRD60Quinoclamine3
iGMDRD64Parbendazole2
iGMDRD506Fedratinib1
iGMDRD577BIX012943
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine2
iGMDRD188Piperlongumine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PEAK1

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