PIK3R1
Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphoinositide-3-kinase regulatory subunit 1 | MIM:171833 | Ensembl:ENSG00000145675 | HGNC:HGNC:8979 | PA33312 | 5q13.1 |
GO terms in PIK3R1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001678 | cellular glucose homeostasis |
| BP | IEA | GO:0001953 | negative regulation of cell-matrix adhesion |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006606 | protein import into nucleus |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IDA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IMP | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030183 | B cell differentiation |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | IMP | GO:0033120 | positive regulation of RNA splicing |
| BP | IEA | GO:0034644 | cellular response to UV |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | ISS | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | IDA | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity |
| BP | ISS | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity |
| BP | IEA | GO:0045671 | negative regulation of osteoclast differentiation |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0046326 | positive regulation of glucose import |
| BP | IEA | GO:0046626 | regulation of insulin receptor signaling pathway |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | ISS | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IDA | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| BP | IPI | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0051492 | regulation of stress fiber assembly |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0060396 | growth hormone receptor signaling pathway |
| BP | IMP | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response |
| BP | ISS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | ISS | GO:2001275 | positive regulation of glucose import in response to insulin stimulus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005801 | cis-Golgi network |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | ISS | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | ISS | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:1990578 | perinuclear endoplasmic reticulum membrane |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | ISS | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
| MF | IPI | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IPI | GO:0005168 | neurotrophin TRKA receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | ISS | GO:0035014 | phosphatidylinositol 3-kinase regulator activity |
| MF | IEA | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding |
| MF | IDA | GO:0043125 | ErbB-3 class receptor binding |
| MF | ISS | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IDA | GO:0043559 | insulin binding |
| MF | ISS | GO:0043560 | insulin receptor substrate binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IBA | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: PIK3R1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3R1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | epopathway | EPO signaling pathway |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | hedgehog_2pathway | Signaling events mediated by the Hedgehog family |
| pid | ifngpathway | IFN-gamma pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | reelinpathway | Reelin signaling pathway |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | trail_pathway | TRAIL signaling pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| pharmgkb | PA153627758 | Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP61 | Notch Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250342 | PI3K events in ERBB4 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373753 | Nephrin family interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-430116 | GP1b-IX-V activation signalling |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654689 | PI-3K cascade:FGFR1 |
| reactome | R-HSA-5654695 | PI-3K cascade:FGFR2 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654710 | PI-3K cascade:FGFR3 |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654720 | PI-3K cascade:FGFR4 |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655291 | Signaling by FGFR4 in disease |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8851907 | MET activates PI3K/AKT signaling |
| reactome | R-HSA-8853334 | Signaling by FGFR3 fusions in cancer |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9028335 | Activated NTRK2 signals through PI3K |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | arfpathway | tumor suppressor arf inhibits ribosomal biogenesis |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cdc42racpathway | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | cxcr4pathway | cxcr4 signaling pathway |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | insulinpathway | insulin signaling pathway |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| biocarta | mtorpathway | mtor signaling pathway |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | nkcellspathway | ras-independent pathway in nk cell-mediated cytotoxicity |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | plcpathway | phospholipase c signaling pathway |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | raspathway | ras signaling pathway |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Notch | Notch |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD694 | HG6-64-1 | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD66 | Doxorubicin | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD444 | Tivantinib | 4 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD983 | PI3K pathway inhibitor | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD738 | PP-242 | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD48 | Dexamethasone | 1 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD311 | Dacinostat | 1 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD402 | AKT Inhibitor VIII | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3R1
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.