PIK3R1


Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphoinositide-3-kinase regulatory subunit 1MIM:171833Ensembl:ENSG00000145675HGNC:HGNC:8979PA333125q13.1

GO terms in PIK3R1


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001678cellular glucose homeostasis
BPIEAGO:0001953negative regulation of cell-matrix adhesion
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0006606protein import into nucleus
BPTASGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007411axon guidance
BPIBAGO:0008286insulin receptor signaling pathway
BPIEAGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIDAGO:0014065phosphatidylinositol 3-kinase signaling
BPIMPGO:0014065phosphatidylinositol 3-kinase signaling
BPIEAGO:0016032viral process
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0030168platelet activation
BPIEAGO:0030183B cell differentiation
BPIEAGO:0030335positive regulation of cell migration
BPTASGO:0031295T cell costimulation
BPIEAGO:0032760positive regulation of tumor necrosis factor production
BPISSGO:0032869cellular response to insulin stimulus
BPIMPGO:0033120positive regulation of RNA splicing
BPIEAGO:0034644cellular response to UV
BPIDAGO:0034976response to endoplasmic reticulum stress
BPISSGO:0034976response to endoplasmic reticulum stress
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0038128ERBB2 signaling pathway
BPIDAGO:0042307positive regulation of protein import into nucleus
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0043551regulation of phosphatidylinositol 3-kinase activity
BPISSGO:0043551regulation of phosphatidylinositol 3-kinase activity
BPIEAGO:0045671negative regulation of osteoclast differentiation
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0046326positive regulation of glucose import
BPIEAGO:0046626regulation of insulin receptor signaling pathway
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPISSGO:0046854phosphatidylinositol phosphorylation
BPIDAGO:0048009insulin-like growth factor receptor signaling pathway
BPIPIGO:0048009insulin-like growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPIDAGO:0050821protein stabilization
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0050900leukocyte migration
BPIEAGO:0051492regulation of stress fiber assembly
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:0060396growth hormone receptor signaling pathway
BPIMPGO:1900103positive regulation of endoplasmic reticulum unfolded protein response
BPISSGO:1903078positive regulation of protein localization to plasma membrane
BPISSGO:2001275positive regulation of glucose import in response to insulin stimulus
CCISSGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIEAGO:0005801cis-Golgi network
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIEAGO:0005911cell-cell junction
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCISSGO:0005942phosphatidylinositol 3-kinase complex
CCISSGO:0005943phosphatidylinositol 3-kinase complex, class IA
CCHDAGO:0016020membrane
CCIEAGO:1990578perinuclear endoplasmic reticulum membrane
MFIPIGO:0001784phosphotyrosine residue binding
MFISSGO:0005068transmembrane receptor protein tyrosine kinase adaptor activity
MFIPIGO:0005158insulin receptor binding
MFIPIGO:0005159insulin-like growth factor receptor binding
MFIPIGO:0005168neurotrophin TRKA receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIPIGO:0019903protein phosphatase binding
MFISSGO:0035014phosphatidylinositol 3-kinase regulator activity
MFIEAGO:0036312phosphatidylinositol 3-kinase regulatory subunit binding
MFIDAGO:0043125ErbB-3 class receptor binding
MFISSGO:0043548phosphatidylinositol 3-kinase binding
MFIDAGO:0043559insulin binding
MFISSGO:0043560insulin receptor substrate binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIBAGO:00469351-phosphatidylinositol-3-kinase regulator activity
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: PIK3R1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3R1


DatabasePathway IDPathway Des.
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidavb3_opn_pathwayOsteopontin-mediated events
pidbcr_5pathwayBCR signaling pathway
pidcd40_pathwayCD40/CD40L signaling
pidcdc42_pathwayCDC42 signaling events
pidcxcr3pathwayCXCR3-mediated signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
pidepha2_fwdpathwayEPHA2 forward signaling
pidephbfwdpathwayEPHB forward signaling
pidephrinbrevpathwayEphrin B reverse signaling
pidepopathwayEPO signaling pathway
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
piderbb4_pathwayErbB4 signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfaspathwayFAS (CD95) signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfgf_pathwayFGF signaling pathway
pidgmcsf_pathwayGMCSF-mediated signaling events
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
pidifngpathwayIFN-gamma pathway
pidigf1_pathwayIGF1 pathway
pidil1pathwayIL1-mediated signaling events
pidil23pathwayIL23-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil5_pathwayIL5-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidlymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
pidlysophospholipid_pathwayLPA receptor mediated events
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidncadherinpathwayN-cadherin signaling events
pidnectin_pathwayNectin adhesion pathway
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidnetrin_pathwayNetrin-mediated signaling events
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpdgfrapathwayPDGFR-alpha signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidptp1bpathwaySignaling events mediated by PTP1B
pidreelinpathwayReelin signaling pathway
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pids1p_s1p2_pathwayS1P2 pathway
pidshp2_pathwaySHP2 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidtrail_pathwayTRAIL signaling pathway
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP61Notch Signaling Pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP75Toll-like Receptor Signaling Pathway
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00463Phosphatidylinositol Phosphate Metabolism
smpdbSMP00582Joubert syndrome
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250342PI3K events in ERBB4 signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-180292GAB1 signalosome
reactomeR-HSA-1839117Signaling by cytosolic FGFR1 fusion mutants
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-1963642PI3K events in ERBB2 signaling
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-210993Tie2 Signaling
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373753Nephrin family interactions
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-430116GP1b-IX-V activation signalling
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5637810Constitutive Signaling by EGFRvIII
reactomeR-HSA-5637812Signaling by EGFRvIII in Cancer
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654695PI-3K cascade:FGFR2
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654710PI-3K cascade:FGFR3
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-8851907MET activates PI3K/AKT signaling
reactomeR-HSA-8853334Signaling by FGFR3 fusions in cancer
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9028335Activated NTRK2 signals through PI3K
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-912526Interleukin receptor SHC signaling
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartabadpathwayregulation of bad phosphorylation
biocartabcellsurvivalpathwayb cell survival pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacdc42racpathwayrole of pi3k subunit p85 in regulation of actin organization and cell migration
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
biocartacxcr4pathwaycxcr4 signaling pathway
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartagcrpathwaycorticosteroids and cardioprotection
biocartaghpathwaygrowth hormone signaling pathway
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartahdacpathwaycontrol of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail7pathwayil-7 signal transduction
biocartainsulinpathwayinsulin signaling pathway
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartamtorpathwaymtor signaling pathway
biocartanfatpathwaynfat and hypertrophy of the heart
biocartangfpathwaynerve growth factor pathway (ngf)
biocartankcellspathwayras-independent pathway in nk cell-mediated cytotoxicity
biocartano1pathwayactions of nitric oxide in the heart
biocartapar1pathwaythrombin signaling and protease-activated receptors
biocartapdgfpathwaypdgf signaling pathway
biocartaplcpathwayphospholipase c signaling pathway
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
biocartarac1pathwayrac1 cell motility signaling pathway
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaraspathwayras signaling pathway
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatpopathwaytpo signaling pathway
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_GastrinGastrin
netpathPathway_GhrelinGhrelin
netpathPathway_IL-7IL-7
netpathPathway_IL1IL1
netpathPathway_IL11IL11
netpathPathway_IL2IL2
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_IL6IL6
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
netpathPathway_NotchNotch
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_TCRTCR
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B3
iGMDRD394BX-7954
iGMDRD297Austocystin D1
iGMDRD470Trametinib1
iGMDRD694HG6-64-11
iGMDRD748PHA-6657521
iGMDRD66Doxorubicin1
iGMDRD193Fqi11
iGMDRD546BMS-7548072
iGMDRD781Sirolimus1
iGMDRD483SCH-5290742
iGMDRD136Nutlin-31
iGMDRD387CHIR-990211
iGMDRD889Compound 7d-cis1
iGMDRD190Nilotinib1
iGMDRD444Tivantinib4
iGMDRD451Serdemetan2
iGMDRD356PNU-746542
iGMDRD74Idarubicin2
iGMDRD399Selumetinib2
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed2
iGMDRD983PI3K pathway inhibitor2
iGMDRD870BRD636101
iGMDRD30917AAG1
iGMDRD187BRD98764
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD318PAC-11
iGMDRD138PX 122
iGMDRD270Ciclosporin1
iGMDRD109Gefitinib1
iGMDRD8024-methylfasudil3
iGMDRD123Isoevodiamine2
iGMDRD177Teniposide3
iGMDRD154NSC237662
iGMDRD57Chloropentafluorobenzene1
iGMDRD536PLX-47201
iGMDRD352PD-03259011
iGMDRD499PDMP1
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD738PP-2421
iGMDRD150RITA2
iGMDRD701NVP-AUY9221
iGMDRD79Gemcitabine2
iGMDRD48Dexamethasone1
iGMDRD148Pifithrin-mu1
iGMDRD505Pevonedistat5
iGMDRD300Tozasertib2
iGMDRD42Vorinostat1
iGMDRD871BRD63681
iGMDRD367Ro 28-16752
iGMDRD366PI-1033
iGMDRD434BMS-5369242
iGMDRD289Parthenolide5
iGMDRD77Itraconazole1
iGMDRD311Dacinostat1
iGMDRD158NSC1415406
iGMDRD402AKT Inhibitor VIII2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3R1

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