SIX4


Summary: This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SIX homeobox 4MIM:606342Ensembl:ENSG00000100625HGNC:HGNC:10890PA3579014q23.1

GO terms in SIX4


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006366transcription by RNA polymerase II
BPISSGO:0007519skeletal muscle tissue development
BPIEAGO:0008582regulation of synaptic growth at neuromuscular junction
BPISSGO:0008584male gonad development
BPTASGO:0009653anatomical structure morphogenesis
BPISSGO:0030238male sex determination
BPISSGO:0030910olfactory placode formation
BPIEAGO:0032880regulation of protein localization
BPISSGO:0034504protein localization to nucleus
BPIEAGO:0042472inner ear morphogenesis
BPISSGO:0043066negative regulation of apoptotic process
BPISSGO:0043524negative regulation of neuron apoptotic process
BPISSGO:0043586tongue development
BPISSGO:0045214sarcomere organization
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0046661male sex differentiation
BPIEAGO:0048538thymus development
BPISSGO:0048699generation of neurons
BPIEAGO:0048701embryonic cranial skeleton morphogenesis
BPIBAGO:0048856anatomical structure development
BPISSGO:0050678regulation of epithelial cell proliferation
BPIEAGO:0051451myoblast migration
BPISSGO:0060037pharyngeal system development
BPISSGO:0061055myotome development
BPISSGO:0061197fungiform papilla morphogenesis
BPISSGO:0061551trigeminal ganglion development
BPISSGO:0072075metanephric mesenchyme development
BPISSGO:0072095regulation of branch elongation involved in ureteric bud branching
BPISSGO:0072107positive regulation of ureteric bud formation
BPISSGO:0090190positive regulation of branching involved in ureteric bud morphogenesis
BPISSGO:0098528skeletal muscle fiber differentiation
BPISSGO:1902725negative regulation of satellite cell differentiation
CCIBAGO:0005634nucleus
CCISSGO:0005634nucleus
CCIBAGO:0005667transcription factor complex
CCISSGO:0005737cytoplasm
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding

Gene expression in normal tissue: SIX4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIX4


DatabasePathway IDPathway Des.
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
wikipathwaysWP3595mir-124 predicted interactions with cell cycle and differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine4
iGMDRD780PP-306
iGMDRD398Sepantronium3
iGMDRD577BIX012942
iGMDRD369TGX-1152
iGMDRD444Tivantinib2
iGMDRD524ISX-91
iGMDRD451Serdemetan3
iGMDRD598QS-113
iGMDRD356PNU-746542
iGMDRD23Gossypol3
iGMDRD474Avrainvillamide2
iGMDRD513BML-2592
iGMDRD255SB2250022
iGMDRD8024-methylfasudil2
iGMDRD187BRD98763
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD201SKI II2
iGMDRD446LY 21832404
iGMDRD163all trans Retinoic Acid2
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD280CYTOCHALASIN B5
iGMDRD466Chaetocin3
iGMDRD375GW-4058332
iGMDRD210AC556491
iGMDRD554CHEMBL14341371
iGMDRD126Tipifarnib6
iGMDRD1008SR-II-138A2
iGMDRD387CHIR-990213
iGMDRD889Compound 7d-cis2
iGMDRD427ABT7373
iGMDRD546BMS-7548072
iGMDRD483SCH-5290743
iGMDRD882CIL413
iGMDRD286Nsc 6328392
iGMDRD269Purmorphamine1
iGMDRD329Merck602
iGMDRD137Indisulam9
iGMDRD158NSC1415402
iGMDRD202Curcumin2
iGMDRD278TTNPB2
iGMDRD5Tyrphostin AG 14783
iGMDRD434BMS-5369243
iGMDRD221Tamoxifen3
iGMDRD6AM-5803
iGMDRD351GW843682X1
iGMDRD123Isoevodiamine2
iGMDRD84Lovastatin acid2
iGMDRD584VER 1550082
iGMDRD512nutlin 33
iGMDRD607Ubistatin B3
iGMDRD345Compound 10b [PMID: 11504634]5
iGMDRD424Tamatinib3
iGMDRD150RITA3
iGMDRD405PIK-752
iGMDRD701NVP-AUY9225

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIX4

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