TTK
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TTK protein kinase | MIM:604092 | Ensembl:ENSG00000112742 | HGNC:HGNC:12401 | PA37066 | 6q14.1 |
GO terms in TTK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007051 | spindle organization |
| BP | TAS | GO:0007052 | mitotic spindle organization |
| BP | TAS | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IEA | GO:0016321 | female meiosis chromosome segregation |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0033316 | meiotic spindle assembly checkpoint |
| BP | IEA | GO:0034501 | protein localization to kinetochore |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0051304 | chromosome separation |
| BP | IEA | GO:1903096 | protein localization to meiotic spindle midzone |
| CC | IEA | GO:0000776 | kinetochore |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005819 | spindle |
| CC | HDA | GO:0016020 | membrane |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: TTK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD322 | FK 866 | 4 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD871 | BRD6368 | 8 |
| iGMDRD289 | Parthenolide | 7 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 7 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD64 | Parbendazole | 7 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 5 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD379 | BIBR-1532 | 3 |
| iGMDRD227 | Fatostatin A | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD499 | PDMP | 5 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD887 | Compound 23 citrate | 5 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD599 | Salermide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTK
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.