ADAMTS2


Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAM metallopeptidase with thrombospondin type 1 motif 2MIM:604539Ensembl:ENSG00000087116HGNC:HGNC:218PA245465q35.3

GO terms in ADAMTS2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007283spermatogenesis
BPIEAGO:0016485protein processing
BPIEAGO:0030199collagen fibril organization
BPIEAGO:0030324lung development
BPIEAGO:0030574collagen catabolic process
BPIEAGO:0043588skin development
CCTASGO:0005576extracellular region
CCIEAGO:0062023collagen-containing extracellular matrix
MFTASGO:0004222metalloendopeptidase activity
MFTASGO:0008237metallopeptidase activity
MFIEAGO:0008270zinc ion binding

Gene expression in normal tissue: ADAMTS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAMTS2


DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-1643685Disease
reactomeR-HSA-1650814Collagen biosynthesis and modifying enzymes
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5173214O-glycosylation of TSR domain-containing proteins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD201SKI II3
iGMDRD107Valdecoxib3
iGMDRD446LY 21832401
iGMDRD152179324-69-72
iGMDRD163all trans Retinoic Acid3
iGMDRD2PK-111953
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD634SCHEMBL26080417
iGMDRD554CHEMBL14341374
iGMDRD126Tipifarnib3
iGMDRD579PF7505
iGMDRD772BRD47703
iGMDRD420Leucascandrolide A5
iGMDRD866BRD18123
iGMDRD599Salermide1
iGMDRD546BMS-7548072
iGMDRD427ABT7375
iGMDRD670ML 2102
iGMDRD494Neopeltolide3
iGMDRD398Sepantronium2
iGMDRD562Navitoclax6
iGMDRD888Compound 443
iGMDRD577BIX012942
iGMDRD369TGX-1153
iGMDRD690PRIMA-1MET3
iGMDRD356PNU-746543
iGMDRD268Cerulenin3
iGMDRD23Gossypol5
iGMDRD474Avrainvillamide2
iGMDRD782DC-45-A27
iGMDRD207Capsaicin4
iGMDRD52Rotenone2
iGMDRD441TW 374
iGMDRD318PAC-12
iGMDRD85Ursolic acid5
iGMDRD351GW843682X1
iGMDRD314Tanespimycin2
iGMDRD211(1S,3R)-RSL33
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD511CHEMBL3993792
iGMDRD330BRD41323
iGMDRD307Manumycin A2
iGMDRD148Pifithrin-mu3
iGMDRD299ICL 6702
iGMDRD532Olaparib1
iGMDRD116CD4371
iGMDRD560MK-22062
iGMDRD286Nsc 6328393
iGMDRD414MST-3121
iGMDRD269Purmorphamine3
iGMDRD552AZD-17752
iGMDRD300Tozasertib3
iGMDRD82Quiflapon4
iGMDRD251ML1622
iGMDRD271Brefeldin A1
iGMDRD137Indisulam5
iGMDRD103SN-381
iGMDRD5Tyrphostin AG 14784
iGMDRD6AM-5803
iGMDRD221Tamoxifen5
iGMDRD267Oligomycin A1
iGMDRD213SMR0000686503

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTS2

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