AFDN


Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
afadin, adherens junction formation factorMIM:159559Ensembl:ENSG00000130396HGNC:HGNC:7137PA308536q27

GO terms in AFDN


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0008022protein C-terminus binding
MFIDAGO:0017016Ras GTPase binding
MFHDAGO:0045296cadherin binding
MFIBAGO:0050839cell adhesion molecule binding
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005911cell-cell junction
CCIBAGO:0005913cell-cell adherens junction
CCIDAGO:0016607nuclear speck
CCIDAGO:0030054cell junction
BPIEAGO:0007155cell adhesion
BPIEAGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIBAGO:0032880regulation of protein localization
BPTASGO:0034332adherens junction organization
BPIMPGO:0043547positive regulation of GTPase activity
BPIMPGO:0090557establishment of endothelial intestinal barrier

Gene expression in normal tissue: AFDN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AFDN


DatabasePathway IDPathway Des.
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
reactomeR-HSA-446728Cell junction organization
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP4223Ras Signaling
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
pidecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidnectin_pathwayNectin adhesion pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidshp2_pathwaySHP2 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832402
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside3
iGMDRD193Fqi15
iGMDRD394BX-7951
iGMDRD466Chaetocin3
iGMDRD634SCHEMBL26080413
iGMDRD126Tipifarnib2
iGMDRD433Lexibulin2
iGMDRD151CHM-15
iGMDRD889Compound 7d-cis3
iGMDRD1008SR-II-138A2
iGMDRD772BRD47701
iGMDRD420Leucascandrolide A6
iGMDRD427ABT7373
iGMDRD144NSC953972
iGMDRD494Neopeltolide3
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD781Sirolimus4
iGMDRD100Zebularine3
iGMDRD188Piperlongumine5
iGMDRD399Selumetinib3
iGMDRD887Compound 23 citrate2
iGMDRD506Fedratinib2
iGMDRD577BIX0129411
iGMDRD562Navitoclax6
iGMDRD64Parbendazole5
iGMDRD60Quinoclamine2
iGMDRD23Gossypol6
iGMDRD451Serdemetan1
iGMDRD138PX 123
iGMDRD260FQI-21
iGMDRD255SB2250024
iGMDRD171Pemetrexed4
iGMDRD441TW 374
iGMDRD341Triacsin c7
iGMDRD351GW843682X1
iGMDRD314Tanespimycin2
iGMDRD237ABT-7511
iGMDRD123Isoevodiamine4
iGMDRD605AZD64821
iGMDRD945ML2143
iGMDRD607Ubistatin B3
iGMDRD116CD4374
iGMDRD560MK-22061
iGMDRD150RITA6
iGMDRD286Nsc 6328393
iGMDRD662JQ-12
iGMDRD366PI-1033
iGMDRD505Pevonedistat5
iGMDRD263AACOCF32
iGMDRD552AZD-17752
iGMDRD246NPC264
iGMDRD103SN-384
iGMDRD137Indisulam2
iGMDRD158NSC1415403
iGMDRD289Parthenolide6
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369241
iGMDRD77Itraconazole2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AFDN

​​​​