FGFR2
Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor receptor 2 | MIM:176943 | Ensembl:ENSG00000066468 | HGNC:HGNC:3689 | PA28128 | 10q26.13 |
GO terms in FGFR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005938 | cell cortex |
| CC | IDA | GO:0009986 | cell surface |
| CC | NAS | GO:0016020 | membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031012 | extracellular matrix |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0043235 | receptor complex |
| CC | ISS | GO:0060076 | excitatory synapse |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001657 | ureteric bud development |
| BP | ISS | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001837 | epithelial to mesenchymal transition |
| BP | ISS | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | ISS | GO:0003148 | outflow tract septum morphogenesis |
| BP | ISS | GO:0003149 | membranous septum morphogenesis |
| BP | IEA | GO:0003416 | endochondral bone growth |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007409 | axonogenesis |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IGI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IPI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | ISS | GO:0008589 | regulation of smoothened signaling pathway |
| BP | ISS | GO:0009791 | post-embryonic development |
| BP | ISS | GO:0009880 | embryonic pattern specification |
| BP | ISS | GO:0009887 | animal organ morphogenesis |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | ISS | GO:0010453 | regulation of cell fate commitment |
| BP | IMP | GO:0010518 | positive regulation of phospholipase activity |
| BP | ISS | GO:0016331 | morphogenesis of embryonic epithelium |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0021769 | orbitofrontal cortex development |
| BP | ISS | GO:0021847 | ventricular zone neuroblast division |
| BP | ISS | GO:0021860 | pyramidal neuron development |
| BP | ISS | GO:0022612 | gland morphogenesis |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | ISS | GO:0030282 | bone mineralization |
| BP | ISS | GO:0030324 | lung development |
| BP | ISS | GO:0030855 | epithelial cell differentiation |
| BP | ISS | GO:0030901 | midbrain development |
| BP | ISS | GO:0030916 | otic vesicle formation |
| BP | ISS | GO:0031069 | hair follicle morphogenesis |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | ISS | GO:0032808 | lacrimal gland development |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | TAS | GO:0033688 | regulation of osteoblast proliferation |
| BP | ISS | GO:0035264 | multicellular organism growth |
| BP | ISS | GO:0035265 | organ growth |
| BP | ISS | GO:0035602 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow |
| BP | ISS | GO:0035603 | fibroblast growth factor receptor signaling pathway involved in hemopoiesis |
| BP | ISS | GO:0035604 | fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow |
| BP | ISS | GO:0035607 | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | ISS | GO:0040014 | regulation of multicellular organism growth |
| BP | ISS | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0042060 | wound healing |
| BP | ISS | GO:0042472 | inner ear morphogenesis |
| BP | ISS | GO:0042476 | odontogenesis |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0045165 | cell fate commitment |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | TAS | GO:0045667 | regulation of osteoblast differentiation |
| BP | ISS | GO:0045787 | positive regulation of cell cycle |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | ISS | GO:0048286 | lung alveolus development |
| BP | IEA | GO:0048333 | mesodermal cell differentiation |
| BP | ISS | GO:0048557 | embryonic digestive tract morphogenesis |
| BP | ISS | GO:0048562 | embryonic organ morphogenesis |
| BP | ISS | GO:0048565 | digestive tract development |
| BP | ISS | GO:0048568 | embryonic organ development |
| BP | ISS | GO:0048608 | reproductive structure development |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IMP | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | TAS | GO:0048705 | skeletal system morphogenesis |
| BP | ISS | GO:0048730 | epidermis morphogenesis |
| BP | ISS | GO:0048755 | branching morphogenesis of a nerve |
| BP | ISS | GO:0048762 | mesenchymal cell differentiation |
| BP | ISS | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | ISS | GO:0051150 | regulation of smooth muscle cell differentiation |
| BP | ISS | GO:0051781 | positive regulation of cell division |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| BP | ISS | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | ISS | GO:0060174 | limb bud formation |
| BP | ISS | GO:0060348 | bone development |
| BP | ISS | GO:0060349 | bone morphogenesis |
| BP | ISS | GO:0060442 | branching involved in prostate gland morphogenesis |
| BP | ISS | GO:0060445 | branching involved in salivary gland morphogenesis |
| BP | ISS | GO:0060449 | bud elongation involved in lung branching |
| BP | ISS | GO:0060463 | lung lobe morphogenesis |
| BP | ISS | GO:0060484 | lung-associated mesenchyme development |
| BP | ISS | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| BP | ISS | GO:0060512 | prostate gland morphogenesis |
| BP | ISS | GO:0060523 | prostate epithelial cord elongation |
| BP | ISS | GO:0060527 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
| BP | ISS | GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development |
| BP | ISS | GO:0060595 | fibroblast growth factor receptor signaling pathway involved in mammary gland specification |
| BP | ISS | GO:0060601 | lateral sprouting from an epithelium |
| BP | ISS | GO:0060615 | mammary gland bud formation |
| BP | ISS | GO:0060664 | epithelial cell proliferation involved in salivary gland morphogenesis |
| BP | ISS | GO:0060667 | branch elongation involved in salivary gland morphogenesis |
| BP | ISS | GO:0060670 | branching involved in labyrinthine layer morphogenesis |
| BP | ISS | GO:0060687 | regulation of branching involved in prostate gland morphogenesis |
| BP | ISS | GO:0060688 | regulation of morphogenesis of a branching structure |
| BP | ISS | GO:0060915 | mesenchymal cell differentiation involved in lung development |
| BP | ISS | GO:0060916 | mesenchymal cell proliferation involved in lung development |
| BP | ISS | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | ISS | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | NAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | IGI | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | NAS | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008201 | heparin binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IDA | GO:0017134 | fibroblast growth factor binding |
| MF | IPI | GO:0017134 | fibroblast growth factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
Gene expression in normal tissue: FGFR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGFR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839126 | FGFR2 mutant receptor activation |
| reactome | R-HSA-1839126 | FGFR2 mutant receptor activation |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-190241 | FGFR2 ligand binding and activation |
| reactome | R-HSA-190375 | FGFR2c ligand binding and activation |
| reactome | R-HSA-190377 | FGFR2b ligand binding and activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2023837 | Signaling by FGFR2 amplification mutants |
| reactome | R-HSA-2033519 | Activated point mutants of FGFR2 |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 |
| reactome | R-HSA-5654695 | PI-3K cascade:FGFR2 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654699 | SHC-mediated cascade:FGFR2 |
| reactome | R-HSA-5654700 | FRS-mediated FGFR2 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-8851708 | Signaling by FGFR2 IIIa TM |
| reactome | R-HSA-8853333 | Signaling by FGFR2 fusions |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| pid | fgf_pathway | FGF signaling pathway |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD3 | PD-173074 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD400 | A-443654 | 1 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD551 | Ponatinib | 9 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD911 | FGFR inhibitor | 31 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD674 | Dovitinib | 9 |
| iGMDRD402 | AKT Inhibitor VIII | 1 |
| iGMDRD1003 | selective FGFR inhibitor | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD397 | Pazopanib | 2 |
| iGMDRD427 | ABT737 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGFR2
CLASSFICATION
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