JARID2


Summary: This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
jumonji and AT-rich interaction domain containing 2MIM:601594Ensembl:ENSG00000008083HGNC:HGNC:6196PA299956p22.3

GO terms in JARID2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIBAGO:0003682chromatin binding
MFISSGO:0003682chromatin binding
MFIEAGO:0008134transcription factor binding
MFIBAGO:0032452histone demethylase activity
MFISSGO:0032452histone demethylase activity
MFIBAGO:0034647histone demethylase activity (H3-trimethyl-K4 specific)
MFIBAGO:0035064methylated histone binding
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001889liver development
BPIEAGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0007417central nervous system development
BPIEAGO:0010614negative regulation of cardiac muscle hypertrophy
BPISSGO:0031061negative regulation of histone methylation
BPTASGO:0045814negative regulation of gene expression, epigenetic
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0048536spleen development
BPIEAGO:0048538thymus development
BPISSGO:0048863stem cell differentiation
BPISSGO:0051574positive regulation of histone H3-K9 methylation
BPIEAGO:0060044negative regulation of cardiac muscle cell proliferation
BPIEAGO:1990830cellular response to leukemia inhibitory factor
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
CCIBAGO:0035097histone methyltransferase complex
CCISSGO:0035097histone methyltransferase complex
CCIDAGO:0035098ESC/E(Z) complex

Gene expression in normal tissue: JARID2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JARID2


DatabasePathway IDPathway Des.
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-212300PRC2 methylates histones and DNA
reactomeR-HSA-74160Gene expression (Transcription)
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2916Interactome of polycomb repressive complex 2 (PRC2)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD79Gemcitabine4
iGMDRD560MK-22062
iGMDRD532Olaparib3
iGMDRD116CD4375
iGMDRD424Tamatinib1
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD512nutlin 33
iGMDRD486Tosedostat2
iGMDRD154NSC237666
iGMDRD883CIL55A1
iGMDRD945ML2143
iGMDRD211(1S,3R)-RSL33
iGMDRD177Teniposide6
iGMDRD123Isoevodiamine5
iGMDRD314Tanespimycin3
iGMDRD105Triptolide4
iGMDRD434BMS-5369244
iGMDRD103SN-383
iGMDRD158NSC1415407
iGMDRD137Indisulam3
iGMDRD322FK 8661
iGMDRD886Compound 1541A1
iGMDRD505Pevonedistat7
iGMDRD246NPC264
iGMDRD366PI-1033
iGMDRD414MST-3126
iGMDRD286Nsc 6328395
iGMDRD872BRD71372
iGMDRD494Neopeltolide2
iGMDRD781Sirolimus3
iGMDRD144NSC953972
iGMDRD599Salermide3
iGMDRD420Leucascandrolide A2
iGMDRD1008SR-II-138A2
iGMDRD126Tipifarnib2
iGMDRD433Lexibulin6
iGMDRD151CHM-13
iGMDRD297Austocystin D5
iGMDRD639YK 4-2793
iGMDRD193Fqi15
iGMDRD446LY 21832402
iGMDRD885Compound 1102
iGMDRD870BRD636103
iGMDRD187BRD98764
iGMDRD171Pemetrexed3
iGMDRD260FQI-22
iGMDRD8024-methylfasudil2
iGMDRD138PX 124
iGMDRD356PNU-746542
iGMDRD23Gossypol1
iGMDRD268Cerulenin2
iGMDRD451Serdemetan4
iGMDRD690PRIMA-1MET2
iGMDRD60Quinoclamine1
iGMDRD64Parbendazole6
iGMDRD577BIX012942
iGMDRD506Fedratinib3
iGMDRD100Zebularine2
iGMDRD188Piperlongumine4
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JARID2

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