PDGFRA


Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
platelet derived growth factor receptor alphaMIM:173490Ensembl:ENSG00000134853HGNC:HGNC:8803PA331474q12

GO terms in PDGFRA


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPISSGO:0001553luteinization
BPIEAGO:0001701in utero embryonic development
BPTASGO:0001775cell activation
BPIEAGO:0002244hematopoietic progenitor cell differentiation
BPIMPGO:0007204positive regulation of cytosolic calcium ion concentration
BPIBAGO:0007275multicellular organism development
BPIEAGO:0008210estrogen metabolic process
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0010544negative regulation of platelet activation
BPIMPGO:0010863positive regulation of phospholipase C activity
BPTASGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0016032viral process
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0023019signal transduction involved in regulation of gene expression
BPIBAGO:0030154cell differentiation
BPIEAGO:0030198extracellular matrix organization
BPIEAGO:0030324lung development
BPIEAGO:0030325adrenal gland development
BPIDAGO:0030335positive regulation of cell migration
BPIMPGO:0030335positive regulation of cell migration
BPIEAGO:0030539male genitalia development
BPIEAGO:0033327Leydig cell differentiation
BPIBAGO:0033674positive regulation of kinase activity
BPIDAGO:0034614cellular response to reactive oxygen species
BPIMPGO:0035790platelet-derived growth factor receptor-alpha signaling pathway
BPIDAGO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
BPISSGO:0042060wound healing
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPIMPGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIDAGO:0048008platelet-derived growth factor receptor signaling pathway
BPIMPGO:0048015phosphatidylinositol-mediated signaling
BPIDAGO:0048146positive regulation of fibroblast proliferation
BPISSGO:0048557embryonic digestive tract morphogenesis
BPIBAGO:0048701embryonic cranial skeleton morphogenesis
BPISSGO:0048701embryonic cranial skeleton morphogenesis
BPISSGO:0048704embryonic skeletal system morphogenesis
BPIMPGO:0050920regulation of chemotaxis
BPTASGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0055003cardiac myofibril assembly
BPIEAGO:0060021roof of mouth development
BPIEAGO:0060325face morphogenesis
BPIMPGO:0060326cell chemotaxis
BPISSGO:0061298retina vasculature development in camera-type eye
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070527platelet aggregation
BPIEAGO:0071230cellular response to amino acid stimulus
BPISSGO:0072277metanephric glomerular capillary formation
BPTASGO:2000249regulation of actin cytoskeleton reorganization
BPIMPGO:2000739regulation of mesenchymal stem cell differentiation
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIEAGO:0005902microvillus
CCIEAGO:0009897external side of plasma membrane
CCHDAGO:0016020membrane
CCIDAGO:0030054cell junction
CCIDAGO:0031226intrinsic component of plasma membrane
CCIDAGO:0032991protein-containing complex
CCIBAGO:0043235receptor complex
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIDAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005018platelet-derived growth factor alpha-receptor activity
MFIDAGO:0005018platelet-derived growth factor alpha-receptor activity
MFIMPGO:0005018platelet-derived growth factor alpha-receptor activity
MFIDAGO:0005021vascular endothelial growth factor-activated receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0019838growth factor binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0038085vascular endothelial growth factor binding
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0044877protein-containing complex binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIBAGO:0048407platelet-derived growth factor binding
MFIDAGO:0048407platelet-derived growth factor binding
MFIPIGO:0048407platelet-derived growth factor binding

Gene expression in normal tissue: PDGFRA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDGFRA


DatabasePathway IDPathway Des.
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP306Focal Adhesion
wikipathwaysWP322Osteoblast Signaling
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
pidatf2_pathwayATF-2 transcription factor network
pidpdgf_pathwayPDGF receptor signaling network
pidpdgfrapathwayPDGFR-alpha signaling pathway
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
biocartacdc42racpathwayrole of pi3k subunit p85 in regulation of actin organization and cell migration
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartapdgfpathwaypdgf signaling pathway
biocartarac1pathwayrac1 cell motility signaling pathway
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201
iGMDRD57Chloropentafluorobenzene3
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD901ELCPK1
iGMDRD512nutlin 33
iGMDRD307Manumycin A2
iGMDRD701NVP-AUY9222
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD3PD-1730741
iGMDRD269Purmorphamine2
iGMDRD415LE-1352
iGMDRD551Ponatinib1
iGMDRD6AM-5804
iGMDRD434BMS-5369242
iGMDRD241Sunitinib10
iGMDRD193Fqi12
iGMDRD446LY 21832401
iGMDRD71Sparfosic acid3
iGMDRD297Austocystin D2
iGMDRD387CHIR-990212
iGMDRD136Nutlin-31
iGMDRD313Axitinib1
iGMDRD494Neopeltolide2
iGMDRD239Dasatinib4
iGMDRD562Navitoclax3
iGMDRD100Zebularine3
iGMDRD887Compound 23 citrate2
iGMDRD451Serdemetan3
iGMDRD413Crenolanib16
iGMDRD134Sorafenib1
iGMDRD270Ciclosporin3
iGMDRD422Regorafenib5
iGMDRD30917AAG1
iGMDRD782DC-45-A23
iGMDRD314Tanespimycin5
iGMDRD352PD-03259011
iGMDRD662JQ-12
iGMDRD976PDGFR inhibitor2
iGMDRD366PI-1032
iGMDRD67PENFLURIDOL3
iGMDRD322FK 8663
iGMDRD467Motesanib1
iGMDRD5Tyrphostin AG 14783
iGMDRD137Indisulam2
iGMDRD121GMX17783
iGMDRD202Curcumin2
iGMDRD77Itraconazole2
iGMDRD105Triptolide1
iGMDRD152179324-69-74
iGMDRD425ERASTIN2
iGMDRD126Tipifarnib3
iGMDRD427ABT7379
iGMDRD188Piperlongumine3
iGMDRD399Selumetinib1
iGMDRD74Idarubicin3
iGMDRD41Imatinib120
iGMDRD356PNU-746542
iGMDRD23Gossypol1
iGMDRD64Parbendazole1
iGMDRD190Nilotinib1
iGMDRD513BML-2591
iGMDRD920HSP90 inhibitor2
iGMDRD8012,4-dideoxy-DC-45-A26
iGMDRD187BRD98762
iGMDRD294Batimastat2
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDGFRA

​​​​