SMARCB1


Summary: The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1MIM:601607Ensembl:ENSG00000099956HGNC:HGNC:11103PA3595322q11.23|22q11

GO terms in SMARCB1


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFHDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFIMPGO:0001164RNA polymerase I CORE element sequence-specific DNA binding
MFIPIGO:0002039p53 binding
MFIDAGO:0003677DNA binding
MFIMPGO:0003713transcription coactivator activity
MFNASGO:0003713transcription coactivator activity
MFIBAGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIPIGO:0030957Tat protein binding
MFHDAGO:0031492nucleosomal DNA binding
CCHDAGO:0000790nuclear chromatin
CCIDAGO:0001650fibrillar center
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0016514SWI/SNF complex
CCIDAGO:0016514SWI/SNF complex
CCHDAGO:0032991protein-containing complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCISSGO:0071564npBAF complex
CCISSGO:0071565nBAF complex
BPIEAGO:0001188RNA polymerase I transcriptional preinitiation complex assembly
BPIBAGO:0006281DNA repair
BPIBAGO:0006337nucleosome disassembly
BPIDAGO:0006337nucleosome disassembly
BPIDAGO:0006338chromatin remodeling
BPIMPGO:0006338chromatin remodeling
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPNASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007049cell cycle
BPIEAGO:0007399nervous system development
BPIBAGO:0008285negative regulation of cell proliferation
BPTASGO:0015074DNA integration
BPIBAGO:0030154cell differentiation
BPIDAGO:0039692single stranded viral RNA replication via double stranded DNA intermediate
BPHDAGO:0043044ATP-dependent chromatin remodeling
BPIBAGO:0043044ATP-dependent chromatin remodeling
BPIMPGO:0043923positive regulation by host of viral transcription
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIMPGO:0090240positive regulation of histone H4 acetylation
BPIMPGO:1900110negative regulation of histone H3-K9 dimethylation
BPIMPGO:1900113negative regulation of histone H3-K9 trimethylation
BPIGIGO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
BPIMPGO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
BPIDAGO:1902661positive regulation of glucose mediated signaling pathway
BPIMPGO:2000617positive regulation of histone H3-K9 acetylation
BPIMPGO:2000618regulation of histone H4-K16 acetylation

Gene expression in normal tissue: SMARCB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMARCB1


DatabasePathway IDPathway Des.
biocartahswisnfpathwaychromatin remodeling by hswi/snf atp-dependent complexes
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214858RMTs methylate histone arginines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
piderb_genomic_pathwayValidated nuclear estrogen receptor beta network
pidrb_1pathwayRegulation of retinoblastoma protein
netpathPathway_TNFalphaTNFalpha
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD414MST-3121
iGMDRD3PD-1730741
iGMDRD886Compound 1541A5
iGMDRD412VX-7021
iGMDRD917HDAC inhibitor2
iGMDRD208Necrosulfonamide1
iGMDRD379BIBR-15321
iGMDRD241Sunitinib1
iGMDRD867BRD18351
iGMDRD178MG-1321
iGMDRD536PLX-47201
iGMDRD351GW843682X2
iGMDRD499PDMP1
iGMDRD177Teniposide1
iGMDRD426WP11301
iGMDRD382CEP-7011
iGMDRD404PD3180881
iGMDRD307Manumycin A1
iGMDRD410Ko-1431
iGMDRD125BIRB-7961
iGMDRD256NVP-2311
iGMDRD701NVP-AUY9225
iGMDRD761KHS1011
iGMDRD887Compound 23 citrate1
iGMDRD577BIX012942
iGMDRD212ML0311
iGMDRD640CAY106181
iGMDRD451Serdemetan7
iGMDRD255SB2250023
iGMDRD907EZH2 inhibitor6
iGMDRD203STF-311
iGMDRD440Nutlin-3A1
iGMDRD30917AAG1
iGMDRD446LY 21832404
iGMDRD280CYTOCHALASIN B3
iGMDRD375GW-4058335
iGMDRD136Nutlin-31
iGMDRD554CHEMBL14341373
iGMDRD313Axitinib1
iGMDRD744EPZ-64382
iGMDRD144NSC953973
iGMDRD286Nsc 6328396
iGMDRD329Merck601
iGMDRD366PI-1031
iGMDRD103SN-383
iGMDRD228ML0291
iGMDRD121GMX17784
iGMDRD137Indisulam1
iGMDRD158NSC1415405
iGMDRD105Triptolide4
iGMDRD197DBeQ1
iGMDRD352PD-03259011
iGMDRD314Tanespimycin3
iGMDRD123Isoevodiamine6
iGMDRD154NSC237665
iGMDRD511CHEMBL3993793
iGMDRD569MOMELOTINIB1
iGMDRD681SB-7439211
iGMDRD321Daporinad1
iGMDRD560MK-22061
iGMDRD405PIK-753
iGMDRD188Piperlongumine5
iGMDRD399Selumetinib2
iGMDRD74Idarubicin3
iGMDRD888Compound 441
iGMDRD190Nilotinib2
iGMDRD171Pemetrexed1
iGMDRD284Palbociclib1
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD294Batimastat1
iGMDRD272GSK-3 Inhibitor IX1
iGMDRD187BRD98763
iGMDRD466Chaetocin3
iGMDRD385CD15301
iGMDRD222HC-0670471
iGMDRD889Compound 7d-cis2
iGMDRD427ABT7373
iGMDRD1Nicotin-Amide1
iGMDRD483SCH-5290743
iGMDRD397Pazopanib1
iGMDRD781Sirolimus2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMARCB1

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