ACACA
Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
acetyl-CoA carboxylase alpha | MIM:200350 | Ensembl:ENSG00000278540 | HGNC:HGNC:84 | PA24421 | 17q12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ACACA
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0001894 | tissue homeostasis |
BP | ISS | GO:0006084 | acetyl-CoA metabolic process |
BP | ISS | GO:0006633 | fatty acid biosynthetic process |
BP | TAS | GO:0006853 | carnitine shuttle |
BP | IEA | GO:0019538 | protein metabolic process |
BP | TAS | GO:0031325 | positive regulation of cellular metabolic process |
BP | TAS | GO:0045540 | regulation of cholesterol biosynthetic process |
BP | TAS | GO:0046949 | fatty-acyl-CoA biosynthetic process |
BP | ISS | GO:0051289 | protein homotetramerization |
BP | IEA | GO:0055088 | lipid homeostasis |
BP | IEA | GO:0071380 | cellular response to prostaglandin E stimulus |
BP | IEA | GO:2001295 | malonyl-CoA biosynthetic process |
CC | IDA | GO:0001650 | fibrillar center |
CC | IDA | GO:0005829 | cytosol |
CC | ISS | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0015629 | actin cytoskeleton |
MF | ISS | GO:0003989 | acetyl-CoA carboxylase activity |
MF | TAS | GO:0003989 | acetyl-CoA carboxylase activity |
MF | IEA | GO:0004075 | biotin carboxylase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IPI | GO:0042802 | identical protein binding |
MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ACACA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACACA
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-163685 | Integration of energy metabolism |
reactome | R-HSA-163765 | ChREBP activates metabolic gene expression |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
reactome | R-HSA-196780 | Biotin transport and metabolism |
reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
reactome | R-HSA-3296482 | Defects in vitamin and cofactor metabolism |
reactome | R-HSA-3323169 | Defects in biotin (Btn) metabolism |
reactome | R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency |
reactome | R-HSA-556833 | Metabolism of lipids |
reactome | R-HSA-5668914 | Diseases of metabolism |
reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
reactome | R-HSA-8957322 | Metabolism of steroids |
reactome | R-HSA-8978868 | Fatty acid metabolism |
biocarta | leptinpathway | reversal of insulin resistance by leptin |
humancyc | PWY-5966-1 | fatty acid biosynthesis initiation |
humancyc | PWY0-1264 | biotin-carboxyl carrier protein assembly |
kegg | hsa00061 | Fatty acid biosynthesis - Homo sapiens (human) |
kegg | hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
kegg | hsa00640 | Propanoate metabolism - Homo sapiens (human) |
kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
netpath | Pathway_Ghrelin | Ghrelin |
pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
smpdb | SMP00016 | Propanoate Metabolism |
smpdb | SMP00060 | Pyruvate Metabolism |
smpdb | SMP00196 | Leigh Syndrome |
smpdb | SMP00198 | Malonic Aciduria |
smpdb | SMP00201 | Methylmalonic Aciduria Due to Cobalamin-Related Disorders |
smpdb | SMP00212 | Pyruvate Dehydrogenase Complex Deficiency |
smpdb | SMP00334 | Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) |
smpdb | SMP00456 | Fatty Acid Biosynthesis |
smpdb | SMP00502 | Malonyl-coa decarboxylase deficiency |
smpdb | SMP00558 | Primary hyperoxaluria II, PH2 |
smpdb | SMP00559 | Pyruvate kinase deficiency |
wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
wikipathways | WP2034 | Leptin signaling pathway |
wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
wikipathways | WP2593 | JAK-STAT |
wikipathways | WP2857 | Mesodermal Commitment Pathway |
wikipathways | WP357 | Fatty Acid Biosynthesis |
wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
wikipathways | WP3934 | Leptin and adiponectin |
wikipathways | WP3965 | Lipid Metabolism Pathway |
wikipathways | WP4010 | Liver steatosis AOP |
wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD945 | ML214 | 3 |
iGMDRD523 | Cyanoquinoline, 11 | 4 |
iGMDRD405 | PIK-75 | 5 |
iGMDRD150 | RITA | 4 |
iGMDRD552 | AZD-1775 | 2 |
iGMDRD367 | Ro 28-1675 | 2 |
iGMDRD871 | BRD6368 | 5 |
iGMDRD77 | Itraconazole | 3 |
iGMDRD396 | AS601245 | 1 |
iGMDRD221 | Tamoxifen | 6 |
iGMDRD705 | Nakiterpiosin | 3 |
iGMDRD289 | Parthenolide | 3 |
iGMDRD103 | SN-38 | 1 |
iGMDRD202 | Curcumin | 5 |
iGMDRD121 | GMX1778 | 2 |
iGMDRD158 | NSC141540 | 2 |
iGMDRD466 | Chaetocin | 2 |
iGMDRD670 | ML 210 | 1 |
iGMDRD546 | BMS-754807 | 2 |
iGMDRD427 | ABT737 | 2 |
iGMDRD889 | Compound 7d-cis | 2 |
iGMDRD151 | CHM-1 | 1 |
iGMDRD874 | BRD8958 | 3 |
iGMDRD23 | Gossypol | 1 |
iGMDRD888 | Compound 44 | 1 |
iGMDRD506 | Fedratinib | 1 |
iGMDRD188 | Piperlongumine | 5 |
iGMDRD260 | FQI-2 | 1 |
iGMDRD474 | Avrainvillamide | 3 |
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
iGMDRD211 | (1S,3R)-RSL3 | 1 |
iGMDRD177 | Teniposide | 4 |
iGMDRD351 | GW843682X | 3 |
iGMDRD116 | CD437 | 5 |
iGMDRD424 | Tamatinib | 2 |
iGMDRD512 | nutlin 3 | 3 |
iGMDRD148 | Pifithrin-mu | 3 |
iGMDRD307 | Manumycin A | 5 |
iGMDRD82 | Quiflapon | 1 |
iGMDRD505 | Pevonedistat | 4 |
iGMDRD246 | NPC26 | 2 |
iGMDRD414 | MST-312 | 3 |
iGMDRD872 | BRD7137 | 4 |
iGMDRD415 | LE-135 | 1 |
iGMDRD267 | Oligomycin A | 4 |
iGMDRD6 | AM-580 | 1 |
iGMDRD271 | Brefeldin A | 1 |
iGMDRD634 | SCHEMBL2608041 | 3 |
iGMDRD297 | Austocystin D | 2 |
iGMDRD280 | CYTOCHALASIN B | 3 |
iGMDRD446 | LY 2183240 | 2 |
iGMDRD201 | SKI II | 3 |
iGMDRD772 | BRD4770 | 1 |
iGMDRD579 | PF750 | 2 |
iGMDRD268 | Cerulenin | 2 |
iGMDRD451 | Serdemetan | 3 |
iGMDRD60 | Quinoclamine | 6 |
iGMDRD577 | BIX01294 | 3 |
iGMDRD562 | Navitoclax | 5 |
iGMDRD318 | PAC-1 | 1 |
iGMDRD885 | Compound 110 | 1 |
iGMDRD441 | TW 37 | 2 |
iGMDRD782 | DC-45-A2 | 3 |
iGMDRD255 | SB225002 | 2 |
iGMDRD138 | PX 12 | 3 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ACACA