AKAP6
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| A-kinase anchoring protein 6 | MIM:604691 | Ensembl:ENSG00000151320 | HGNC:HGNC:376 | PA24670 | 14q12 |
GO terms in AKAP6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IC | GO:0001508 | action potential |
| BP | NAS | GO:0006605 | protein targeting |
| BP | ISS | GO:0010738 | regulation of protein kinase A signaling |
| BP | IC | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| BP | NAS | GO:0019933 | cAMP-mediated signaling |
| BP | ISS | GO:0030307 | positive regulation of cell growth |
| BP | ISS | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | ISS | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| BP | IDA | GO:0060306 | regulation of membrane repolarization |
| BP | ISS | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity |
| BP | ISS | GO:0061051 | positive regulation of cell growth involved in cardiac muscle cell development |
| BP | ISS | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade |
| BP | IDA | GO:0071320 | cellular response to cAMP |
| BP | ISS | GO:0071345 | cellular response to cytokine stimulus |
| BP | IDA | GO:1901381 | positive regulation of potassium ion transmembrane transport |
| BP | IDA | GO:1902261 | positive regulation of delayed rectifier potassium channel activity |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005901 | caveola |
| CC | ISS | GO:0014701 | junctional sarcoplasmic reticulum membrane |
| CC | ISS | GO:0014704 | intercalated disc |
| CC | IBA | GO:0016529 | sarcoplasmic reticulum |
| CC | IDA | GO:0016529 | sarcoplasmic reticulum |
| CC | ISS | GO:0030315 | T-tubule |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0034704 | calcium channel complex |
| CC | IBA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008179 | adenylate cyclase binding |
| MF | ISS | GO:0032947 | protein-containing complex scaffold activity |
| MF | ISS | GO:0034237 | protein kinase A regulatory subunit binding |
| MF | ISS | GO:0043495 | protein membrane anchor |
| MF | IBA | GO:0044325 | ion channel binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | IBA | GO:0051018 | protein kinase A binding |
| MF | NAS | GO:0051018 | protein kinase A binding |
| MF | TAS | GO:0051018 | protein kinase A binding |
Gene expression in normal tissue: AKAP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD782 | DC-45-A2 | 9 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD630 | ML203 | 2 |
| iGMDRD598 | QS-11 | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD359 | OSW-1 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD299 | ICL 670 | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD322 | FK 866 | 7 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP6
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.