HERC2


Summary: This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
HECT and RLD domain containing E3 ubiquitin protein ligase 2MIM:605837Ensembl:ENSG00000128731HGNC:HGNC:4868PA2924315q13.1

Gene Categories:

DNA REPAIR

GO terms in HERC2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004842ubiquitin-protein transferase activity
MFNASGO:0005085guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIDAGO:0032183SUMO binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005814centriole
CCHDAGO:0016020membrane
BPTASGO:0006303double-strand break repair via nonhomologous end joining
BPNASGO:0006886intracellular protein transport
BPIBAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007283spermatogenesis
BPIDAGO:0016567protein ubiquitination
BPIEAGO:0016567protein ubiquitination
BPIBAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process

Gene expression in normal tissue: HERC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HERC2


DatabasePathway IDPathway Des.
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
wikipathwaysWP3998Prader-Willi and Angelman Syndrome
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD427ABT7372
iGMDRD781Sirolimus2
iGMDRD126Tipifarnib7
iGMDRD433Lexibulin3
iGMDRD420Leucascandrolide A5
iGMDRD466Chaetocin3
iGMDRD639YK 4-2791
iGMDRD61Kinetin riboside3
iGMDRD187BRD98763
iGMDRD513BML-2592
iGMDRD474Avrainvillamide2
iGMDRD64Parbendazole2
iGMDRD23Gossypol4
iGMDRD524ISX-92
iGMDRD188Piperlongumine2
iGMDRD399Selumetinib2
iGMDRD74Idarubicin6
iGMDRD888Compound 442
iGMDRD150RITA2
iGMDRD560MK-22062
iGMDRD123Isoevodiamine1
iGMDRD698Neratinib3
iGMDRD237ABT-7515
iGMDRD213SMR0000686501
iGMDRD202Curcumin2
iGMDRD121GMX17787
iGMDRD137Indisulam2
iGMDRD158NSC1415403
iGMDRD147Prima-12
iGMDRD552AZD-17753
iGMDRD322FK 8666
iGMDRD367Ro 28-16752
iGMDRD286Nsc 6328395
iGMDRD329Merck606
iGMDRD144NSC953972
iGMDRD579PF7502
iGMDRD772BRD47702
iGMDRD1008SR-II-138A2
iGMDRD446LY 21832404
iGMDRD193Fqi11
iGMDRD870BRD636101
iGMDRD270Ciclosporin2
iGMDRD138PX 121
iGMDRD255SB2250022
iGMDRD100Zebularine4
iGMDRD887Compound 23 citrate2
iGMDRD577BIX012942
iGMDRD116CD4373
iGMDRD701NVP-AUY9223
iGMDRD486Tosedostat2
iGMDRD307Manumycin A2
iGMDRD512nutlin 34
iGMDRD211(1S,3R)-RSL33
iGMDRD177Teniposide2
iGMDRD351GW843682X6
iGMDRD434BMS-5369242
iGMDRD481Dactolisib2
iGMDRD415LE-1352
iGMDRD267Oligomycin A2
iGMDRD505Pevonedistat3
iGMDRD246NPC263
iGMDRD82Quiflapon2
iGMDRD414MST-3122
iGMDRD872BRD713712
iGMDRD882CIL412

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HERC2

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