KMT2C


Summary: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lysine methyltransferase 2CMIM:606833Ensembl:ENSG00000055609HGNC:HGNC:13726PA308477q36.1

GO terms in KMT2C


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003677DNA binding
MFIBAGO:0003713transcription coactivator activity
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0016746transferase activity, transferring acyl groups
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIBAGO:0042393histone binding
MFIBAGO:0042800histone methyltransferase activity (H3-K4 specific)
MFIDAGO:0042800histone methyltransferase activity (H3-K4 specific)
MFIEAGO:0046872metal ion binding
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0035097histone methyltransferase complex
CCIBAGO:0044666MLL3/4 complex
CCIDAGO:0044666MLL3/4 complex
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0045652regulation of megakaryocyte differentiation
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051568histone H3-K4 methylation

Gene expression in normal tissue: KMT2C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KMT2C


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
kegghsa00310Lysine degradation - Homo sapiens (human)
wikipathwaysWP2369Histone Modifications
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369242
iGMDRD389SB5253342
iGMDRD872BRD71372
iGMDRD505Pevonedistat7
iGMDRD246NPC263
iGMDRD42Vorinostat2
iGMDRD353PD03259011
iGMDRD84Lovastatin acid3
iGMDRD512nutlin 35
iGMDRD424Tamatinib1
iGMDRD351GW843682X8
iGMDRD211(1S,3R)-RSL32
iGMDRD132(-)-gallocatechin-3-O-gallate5
iGMDRD138PX 125
iGMDRD8024-methylfasudil1
iGMDRD255SB2250023
iGMDRD441TW 372
iGMDRD885Compound 1101
iGMDRD100Zebularine3
iGMDRD887Compound 23 citrate1
iGMDRD454JNK Inhibitor VIII1
iGMDRD1008SR-II-138A2
iGMDRD772BRD47703
iGMDRD494Neopeltolide2
iGMDRD446LY 21832404
iGMDRD193Fqi15
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B8
iGMDRD103SN-386
iGMDRD202Curcumin2
iGMDRD121GMX17783
iGMDRD137Indisulam3
iGMDRD705Nakiterpiosin6
iGMDRD105Triptolide4
iGMDRD289Parthenolide2
iGMDRD367Ro 28-16752
iGMDRD329Merck603
iGMDRD366PI-1036
iGMDRD552AZD-17755
iGMDRD322FK 8662
iGMDRD560MK-22061
iGMDRD583LDN 1931891
iGMDRD405PIK-753
iGMDRD237ABT-7511
iGMDRD123Isoevodiamine4
iGMDRD605AZD64821
iGMDRD945ML2142
iGMDRD154NSC237661
iGMDRD883CIL55A1
iGMDRD474Avrainvillamide1
iGMDRD260FQI-26
iGMDRD187BRD98762
iGMDRD188Piperlongumine1
iGMDRD74Idarubicin2
iGMDRD399Selumetinib4
iGMDRD888Compound 443
iGMDRD780PP-305
iGMDRD64Parbendazole4
iGMDRD524ISX-93
iGMDRD76Simvastatin3
iGMDRD433Lexibulin6
iGMDRD151CHM-16
iGMDRD420Leucascandrolide A4
iGMDRD670ML 2104
iGMDRD283Bosutinib1
iGMDRD781Sirolimus5
iGMDRD152179324-69-72
iGMDRD61Kinetin riboside3
iGMDRD679Bistramide A5
iGMDRD466Chaetocin2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KMT2C

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