iGMDRD462


Canonical SMILES: CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

InChI: InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)

InChI Key: PKCDDUHJAFVJJB-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
OSI-906 (Linsitinib)CHEMBL1091644 11640400AloneSmall Molecule

Drug Targets:

FLT1FLT3KDRIGF1RINSR

Drug Pathways:

IGFR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
8241RBM101
2956MSH61
3845KRAS3
3757KCNH21
55215FANCI1
8289ARID1A1
6597SMARCA41
9869SETDB11
83481EPPK11
23235SIK21
4170MCL13
1404HAPLN11
9611NCOR11
8242KDM5C1
5159PDGFRB1
4851NOTCH13
2033EP3001
54477PLEKHA51
27065NSG11
4301AFDN1
25937WWTR11
7416VDAC11
2210FCGR1B1
6850SYK1
659BMPR21
3667IRS11
10413YAP11
1029CDKN2A2
10018BCL2L111
5834PYGB1
4088SMAD31
3673ITGA21
25836NIPBL2
3791KDR1
4086SMAD11
7422VEGFA1
3481IGF22
84181CHD62
4904YBX11
57111RAB251
5290PIK3CA1
675BRCA21
607BCL91
1956EGFR1
54206ERRFI11
8682PEA151
896CCND31
3553IL1B1
5781PTPN111
10752CHL11
5728PTEN2
7385UQCRC21
9748SLK1
1030CDKN2B1
100862685ERVK-191
5054SERPINE11
196528ARID21
8661EIF3A1
142PARP11
84446BRSK11
4763NF12
4613MYCN1
55193PBRM11

Gene in drug-gene network: Network Plot

Models in OSI-906 (Linsitinib)

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