CDK4


Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cyclin dependent kinase 4MIM:123829Ensembl:ENSG00000135446HGNC:HGNC:1773PA10212q14.1

GO terms in CDK4


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIDAGO:0000785chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005667transcription factor complex
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005923bicellular tight junction
CCIDAGO:0031965nuclear membrane
CCIEAGO:0048471perinuclear region of cytoplasm
CCIEAGO:0097129cyclin D2-CDK4 complex
BPIMPGO:0000082G1/S transition of mitotic cell cycle
BPIEAGO:0002088lens development in camera-type eye
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIBAGO:0006468protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0007623circadian rhythm
BPIMPGO:0008284positive regulation of cell proliferation
BPIEAGO:0009636response to toxic substance
BPIEAGO:0010288response to lead ion
BPIMPGO:0010468regulation of gene expression
BPIDAGO:0010971positive regulation of G2/M transition of mitotic cell cycle
BPIEAGO:0031100animal organ regeneration
BPTASGO:0031658negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
BPIEAGO:0032869cellular response to insulin stimulus
BPIEAGO:0033574response to testosterone
BPIEAGO:0040014regulation of multicellular organism growth
BPIEPGO:0042493response to drug
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0045727positive regulation of translation
BPTASGO:0045787positive regulation of cell cycle
BPIEAGO:0045793positive regulation of cell size
BPIEAGO:0046626regulation of insulin receptor signaling pathway
BPIEAGO:0046890regulation of lipid biosynthetic process
BPIMPGO:0048146positive regulation of fibroblast proliferation
BPIEAGO:0050994regulation of lipid catabolic process
BPIEAGO:0051301cell division
BPIEAGO:0055093response to hyperoxia
BPIEAGO:0060612adipose tissue development
BPIDAGO:0071157negative regulation of cell cycle arrest
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:0071353cellular response to interleukin-4
BPIEAGO:1904628cellular response to phorbol 13-acetate 12-myristate
BPIEAGO:1904637cellular response to ionomycin
MFEXPGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIBAGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIDAGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFTASGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIPIGO:0030332cyclin binding
MFIEAGO:0044877protein-containing complex binding

Gene expression in normal tissue: CDK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDK4


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-3214858RMTs methylate histone arginines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69229Ubiquitin-dependent degradation of Cyclin D1
reactomeR-HSA-69229Ubiquitin-dependent degradation of Cyclin D1
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin D
reactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin D
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849470PTK6 Regulates Cell Cycle
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-912446Meiotic recombination
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartaefppathwayestrogen responsive protein efp controls cell cycle and breast tumors growth
biocartag1pathwaycell cycle: g1/s check point
biocartap53pathwayp53 signaling pathway
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
pidatf2_pathwayATF-2 transcription factor network
pidfoxm1pathwayFOXM1 transcription factor network
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidrb_1pathwayRegulation of retinoblastoma protein
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
netpathPathway_BCRBCR
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP179Cell Cycle
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP2878PPAR Alpha Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP34Ovarian Infertility Genes
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3969H19 action Rb-E2F1 signaling and CDK-?-catenin activity
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP707DNA Damage Response

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD42Vorinostat2
iGMDRD300Tozasertib3
iGMDRD935JQ121
iGMDRD271Brefeldin A3
iGMDRD481Dactolisib1
iGMDRD551Ponatinib1
iGMDRD267Oligomycin A8
iGMDRD231Importazole3
iGMDRD6AM-5801
iGMDRD536PLX-47202
iGMDRD351GW843682X1
iGMDRD499PDMP1
iGMDRD435BI-25361
iGMDRD512nutlin 33
iGMDRD701NVP-AUY9221
iGMDRD116CD4371
iGMDRD577BIX012943
iGMDRD562Navitoclax8
iGMDRD887Compound 23 citrate3
iGMDRD60Quinoclamine5
iGMDRD255SB2250021
iGMDRD138PX 121
iGMDRD318PAC-13
iGMDRD727Alpelisib1
iGMDRD30917AAG1
iGMDRD782DC-45-A23
iGMDRD193Fqi11
iGMDRD446LY 21832403
iGMDRD797ISOX DUAL2
iGMDRD375GW-4058333
iGMDRD181CDK4 inhibitor1
iGMDRD229B021
iGMDRD599Salermide1
iGMDRD1008SR-II-138A1
iGMDRD136Nutlin-31
iGMDRD129SB-2167631
iGMDRD144NSC953973
iGMDRD638Ribociclib18
iGMDRD662JQ-13
iGMDRD367Ro 28-16751
iGMDRD552AZD-17751
iGMDRD5Tyrphostin AG 14781
iGMDRD103SN-383
iGMDRD121GMX17783
iGMDRD202Curcumin1
iGMDRD251ML1621
iGMDRD311Dacinostat1
iGMDRD705Nakiterpiosin3
iGMDRD352PD-03259011
iGMDRD698Neratinib1
iGMDRD237ABT-7511
iGMDRD219Bax channel blocker3
iGMDRD883CIL55A3
iGMDRD123Isoevodiamine1
iGMDRD523Cyanoquinoline, 111
iGMDRD506Fedratinib1
iGMDRD399Selumetinib1
iGMDRD182CDK4 inhibitor (tumors with RB expression)1
iGMDRD356PNU-746543
iGMDRD524ISX-91
iGMDRD190Nilotinib1
iGMDRD64Parbendazole1
iGMDRD260FQI-23
iGMDRD52Rotenone1
iGMDRD284Palbociclib7
iGMDRD639YK 4-2793
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside3
iGMDRD2PK-111953
iGMDRD466Chaetocin3
iGMDRD394BX-7953
iGMDRD126Tipifarnib3
iGMDRD433Lexibulin3
iGMDRD151CHM-13
iGMDRD781Sirolimus5
iGMDRD546BMS-7548073

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK4

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